XlyB

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  • Description: N-acetylmuramoyl-L-alanine amidase

Gene name xlyB
Synonyms yjpB
Essential no
Product N-acetylmuramoyl-L-alanine amidase
Function PBSX prophage-mediated lysis
Gene expression levels in SubtiExpress: xlyB
MW, pI 33 kDa, 9.802
Gene length, protein length 951 bp, 317 aa
Immediate neighbours yjpA, yjqA
Sequences Protein DNA DNA_with_flanks
Genetic context
XlyB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
XlyB expression.png















Categories containing this gene/protein

cell wall degradation/ turnover, phage-related functions, PBSX prophage

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU12460

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides (according to Swiss-Prot)
  • Protein family: LysM repeat (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information: the mRNA is very stable (half-life > 15 min) PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Girbe Buist, Anton Steen, Jan Kok, Oscar P Kuipers
LysM, a widely distributed protein motif for binding to (peptido)glycans.
Mol Microbiol: 2008, 68(4);838-47
[PubMed:18430080] [WorldCat.org] [DOI] (I p)

Original publications

G Hambraeus, C von Wachenfeldt, L Hederstedt
Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs.
Mol Genet Genomics: 2003, 269(5);706-14
[PubMed:12884008] [WorldCat.org] [DOI] (P p)