Difference between revisions of "WalJ"

From SubtiWiki
Jump to: navigation, search
Line 22: Line 22:
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yyxA]]'', ''[[yycI]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yyxA]]'', ''[[yycI]]''
 
|-
 
|-
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU40370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU40370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU40370 Advanced_DNA]
+
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU40370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU40370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU40370 DNA_with_flanks]
 
|-
 
|-
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yycJ_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:yycJ_context.gif]]

Revision as of 11:44, 14 May 2013

Gene name walJ
Synonyms yycJ
Essential no
Product unknown
Function coordination of cell division with DNA replication
Gene expression levels in SubtiExpress: walJ
MW, pI 29 kDa, 5.503
Gene length, protein length 804 bp, 268 aa
Immediate neighbours yyxA, yycI
Sequences Protein DNA DNA_with_flanks
Genetic context
YycJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
WalJ expression.png
























Categories containing this gene/protein

cell division, cell wall synthesis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU40370

Phenotypes of a mutant

  • the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited PubMed
  • increased sensitivity to a narrow spectrum of cephalosporin antibiotics PubMed
  • disruption of the corresponding gene in B. anthracis results in a mutator phenotype PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication PubMed
  • Protein family: predicted member of the metallo-β-lactamase superfamily
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949] [WorldCat.org] [DOI] (P p)