Difference between revisions of "WalJ"
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|style="background:#ABCDEF;" align="center"|'''Function''' || coordination of [[cell division]] with DNA replication | |style="background:#ABCDEF;" align="center"|'''Function''' || coordination of [[cell division]] with DNA replication | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU40370 walJ] |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.503 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.503 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yyxA]]'', ''[[yycI]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[yyxA]]'', ''[[yycI]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU40370 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU40370 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU40370 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:yycJ_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:yycJ_context.gif]] | ||
Revision as of 15:19, 13 May 2013
- Description: coordination of cell division with DNA replication
| Gene name | walJ |
| Synonyms | yycJ |
| Essential | no |
| Product | unknown |
| Function | coordination of cell division with DNA replication |
| Gene expression levels in SubtiExpress: walJ | |
| MW, pI | 29 kDa, 5.503 |
| Gene length, protein length | 804 bp, 268 aa |
| Immediate neighbours | yyxA, yycI |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
cell division, cell wall synthesis
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40370
Phenotypes of a mutant
- the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited PubMed
- increased sensitivity to a narrow spectrum of cephalosporin antibiotics PubMed
- disruption of the corresponding gene in B. anthracis results in a mutator phenotype PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication PubMed
- Protein family: predicted member of the metallo-β-lactamase superfamily
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: C0SP91
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949]
[WorldCat.org]
[DOI]
(P p)
