Difference between revisions of "WalJ"

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|style="background:#ABCDEF;" align="center"|'''Function''' || coordination of [[cell division]] with DNA replication
 
|style="background:#ABCDEF;" align="center"|'''Function''' || coordination of [[cell division]] with DNA replication
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU40370 walJ]
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.503   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 5.503   

Revision as of 17:47, 7 August 2012

Gene name walJ
Synonyms yycJ
Essential no
Product unknown
Function coordination of cell division with DNA replication
Gene expression levels in SubtiExpress: walJ
MW, pI 29 kDa, 5.503
Gene length, protein length 804 bp, 268 aa
Immediate neighbours yyxA, yycI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YycJ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
WalJ expression.png
























Categories containing this gene/protein

cell division, cell wall synthesis

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU40370

Phenotypes of a mutant

  • the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited PubMed
  • increased sensitivity to a narrow spectrum of cephalosporin antibiotics PubMed
  • disruption of the corresponding gene in B. anthracis results in a mutator phenotype PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication PubMed
  • Protein family: predicted member of the metallo-β-lactamase superfamily
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949] [WorldCat.org] [DOI] (P p)