Difference between revisions of "WalJ"
| Line 47: | Line 47: | ||
* the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited {{PubMed|21169496}} | * the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited {{PubMed|21169496}} | ||
* increased sensitivity to a narrow spectrum of cephalosporin antibiotics {{PubMed|21169496}} | * increased sensitivity to a narrow spectrum of cephalosporin antibiotics {{PubMed|21169496}} | ||
| + | * disruption of the corresponding gene in B. anthracis results in a mutator phenotype {{PubMed|21205011}} | ||
=== Database entries === | === Database entries === | ||
| Line 126: | Line 127: | ||
=References= | =References= | ||
| − | <pubmed>9829949, | + | <pubmed>9829949, 21205011 </pubmed> |
'''Additional publications:''' {{PubMed|21169496}} | '''Additional publications:''' {{PubMed|21169496}} | ||
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:13, 25 March 2011
- Description: coordination of cell division with DNA replication
| Gene name | walJ |
| Synonyms | yycJ |
| Essential | no |
| Product | unknown |
| Function | coordination of cell division with DNA replication |
| MW, pI | 29 kDa, 5.503 |
| Gene length, protein length | 804 bp, 268 aa |
| Immediate neighbours | yyxA, yycI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
cell division, cell wall synthesis
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40370
Phenotypes of a mutant
- the mutant divides over unsegregated chromosomes more frequently than wild-type cells, and this phenotype is exacerbated when DNA replication is inhibited PubMed
- increased sensitivity to a narrow spectrum of cephalosporin antibiotics PubMed
- disruption of the corresponding gene in B. anthracis results in a mutator phenotype PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: the enzymatic activity of WalJ directly or indirectly affects cell wall metabolism and is required for accurate coordination of cell division with DNA replication PubMed
- Protein family: predicted member of the metallo-β-lactamase superfamily
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: C0SP91
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: expressed during vegetative growth, repressed during stationary phase PubMed
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Hanjing Yang, Cameron Sikavi, Katherine Tran, Shauna M McGillivray, Victor Nizet, Madeline Yung, Aileen Chang, Jeffrey H Miller
Papillation in Bacillus anthracis colonies: a tool for finding new mutators.
Mol Microbiol: 2011, 79(5);1276-93
[PubMed:21205011]
[WorldCat.org]
[DOI]
(I p)
C Fabret, J A Hoch
A two-component signal transduction system essential for growth of Bacillus subtilis: implications for anti-infective therapy.
J Bacteriol: 1998, 180(23);6375-83
[PubMed:9829949]
[WorldCat.org]
[DOI]
(P p)
Additional publications: PubMed
