VmlR

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  • Description: ABC transporter (ATP-binding protein), efflux of antibiotics (virginiamycin M, lincomycin)

Gene name vmlR
Synonyms expZ
Essential no
Product antibiotic efflux ABC transporter (ATP-binding protein)
Function efflux of antibiotics (virginiamycin M, lincomycin)
Gene expression levels in SubtiExpress: vmlR
MW, pI 62 kDa, 6.727
Gene length, protein length 1641 bp, 547 aa
Immediate neighbours ydgE, ydgF
Sequences Protein DNA Advanced_DNA
Genetic context
ExpZ context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
VmlR expression.png
























Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics

This gene is a member of the following regulons

RNA switch/ other

The gene

Basic information

  • Locus tag: BSU05610

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: induced by virginiamycin M or lincomycin PubMed
  • Regulatory mechanism: transcriptional antitermination, details are unknown PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Irnov Irnov, Cynthia M Sharma, Jörg Vogel, Wade C Winkler
Identification of regulatory RNAs in Bacillus subtilis.
Nucleic Acids Res: 2010, 38(19);6637-51
[PubMed:20525796] [WorldCat.org] [DOI] (I p)

Reiko Ohki, Kozue Tateno, Teruaki Takizawa, Toshiko Aiso, Makiko Murata
Transcriptional termination control of a novel ABC transporter gene involved in antibiotic resistance in Bacillus subtilis.
J Bacteriol: 2005, 187(17);5946-54
[PubMed:16109936] [WorldCat.org] [DOI] (P p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)