upp

upp
168

uracil phosphoribosyltransferase

locus
BSU_36890
Molecular weight
22.89 kDa
pI
5.86
Protein length
Gene length
function
UMP synthesis
product
uracil phosphoribosyltransferase
essential
no
ec
2.4.2.9
synonyms
upp, ipc-35d

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0035 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
3,788,426  3,789,055
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The protein
Catalyzed reaction/ biological activity
diphosphate + UMP --> 5-phospho-α-D-ribose 1-diphosphate + uracil (according to UniProt)
Protein family
UPRTase family (single member, according to UniProt)
Structure
[PDB|2EHJ] (from ''Escherichia coli'', 52% identity, 73% similarity)
[AF|P39149]
Expression and Regulation
Operons
genes
[gene|A92A17CAE2EF33C320B958325F9728EA0FD98F85|upp]
description
[Pubmed|9353933]
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[gene|A92A17CAE2EF33C320B958325F9728EA0FD98F85|upp]

2024-03-17 19:54:15

ghost

34

5b6d07109482e761a99c37bac81017b7fb70f119

7AFED01A3A8B31274B2D1219E39AEBCE42630E25

Biological materials
Mutant
1A832 (no resistance), [Pubmed|12366828], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A832&Search=1A832 BGSC]
BKE36890 ([gene|A92A17CAE2EF33C320B958325F9728EA0FD98F85|upp]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE36890 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATACTGTGTTTCAGCTCCT,  downstream forward: _UP4_TAAAAAATGAAATCCCCAAA
BKK36890 ([gene|A92A17CAE2EF33C320B958325F9728EA0FD98F85|upp]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK36890 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATACTGTGTTTCAGCTCCT,  downstream forward: _UP4_TAAAAAATGAAATCCCCAAA
References
36815589,7798145

A92A17CAE2EF33C320B958325F9728EA0FD98F85

Page visits: 1930

Time of last update: 2024-03-28 10:38:20

Author of last update: Jstuelk