tyrS
168
tyrosyl-tRNA synthetase (major)
locus
BSU_29670
Molecular weight
47.57 kDa
pI
5.21
function
translation
product
tyrosyl-tRNA synthetase (major)
essential
quasi
ec
6.1.1.1
synonyms
tyrS
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0162 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,036,603 3,037,871
Phenotypes of a mutant
essential [Pubmed|12682299]
quasi-essential, the gene can be deleted, but the mutant acquires suppressors in [gene|2D4E3D6C3634C3F42A4517D5C1A8F4F48CAFF3A6|dtrR] to allow expression of [gene|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ] [Pubmed|25733610]
a [gene|EEB0CF0AF0707AC1161F150708F7EDDB749B3C42|tyrS] [gene|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ] double mutant is not viable [Pubmed|25733610]
The protein
Catalyzed reaction/ biological activity
ATP + L-tyrosine + tRNATyr --> AMP + diphosphate + H+ + L-tyrosyl-tRNATyr (according to UniProt)
Protein family
[wiki|S4 RNA-binding domain] superfamily (according to http://www.ebi.ac.uk/interpro/entry/IPR036986 Interpro)
[wiki|Class-I aminoacyl-tRNA synthetase family] (according to UniProt)
[wiki|Domains]
[wiki|S4 RNA-binding domain] (aa 355-421) (according to UniProt)
Structure
[PDB|3TS1] (complex with tyrosyl adenylate intermediate, Geobacillus stearothermophilus)
[PDB|1JH3] (C-terminal domain, Geobacillus stearothermophilus)
[PDB|1N53] (the [regulon|T-box] antiterminator RNA) [Pubmed|12547201]
[AF|P22326]
Paralogous protein(s)
[protein|1968743631A20739B5DA8B489CB1E7E42F3B93E3|tyrZ]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
References
Reviews
Original Publications
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Time of last update: 2024-04-24 06:37:24
Author of last update: Jstuelk