TyrA

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  • Description: prephenate dehydrogenase

Gene name tyrA
Synonyms
Essential no
Product prephenate dehydrogenase
Function biosynthesis of tyrosine
Gene expression levels in SubtiExpress: tyrA
Metabolic function and regulation of this protein in SubtiPathways:
tyrA
MW, pI 41 kDa, 5.471
Gene length, protein length 1113 bp, 371 aa
Immediate neighbours aroE, hisC
Sequences Protein DNA DNA_with_flanks
Genetic context
TyrA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
TyrA expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

TRAP regulon

The gene

Basic information

  • Locus tag: BSU22610

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH (according to Swiss-Prot)
  • Protein family: HisMQ subfamily (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: subject to feedback inhibtion by tyrosine PubMed

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • TRAP: binding to the mRNA in the presence of tryptophan, this results in transcription termination PubMed
  • Additional information:
    • the mRNA is substantially stabilized upon depletion of RNase Y PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References