Difference between revisions of "Two-component systems"

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(Related lists)
(The phosphorelay)
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** [[KinE]]
 
** [[KinE]]
  
* Phosphotranferases
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* Phosphotransferases
 
** [[Spo0F]]
 
** [[Spo0F]]
 
** [[Spo0B]]
 
** [[Spo0B]]

Revision as of 18:35, 20 May 2010

Two component systems are signal transduction systems that consist of a sensor kinase and a response regulator (usually a transcription factor). The kinase autophosphorylates on a His residue (more preciely, one subunit of the dimeric kinase phosphorylates the His residue of the other subunit), and the phosphate group can then be transferred to an aspartate residue in the cognate response regulator. Some response regulators can also autophosphorylate using acety-phosphate as the phosphate donor. More complex signal transduction systems of this class are called phosphorelay. The paradigm for a phosphorelay is the pathway leading to the phosphorylation of Spo0A.

Two-component systems in B. subtilis (kinase, regulator)

  • Orphan response regulator

The phosphorelay

  • The ultimate target

Related lists

Reviews

Hendrik Szurmant, James A Hoch
Interaction fidelity in two-component signaling.
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[PubMed:20133181] [WorldCat.org] [DOI] (I p)

Kristin Wuichet, Brian J Cantwell, Igor B Zhulin
Evolution and phyletic distribution of two-component signal transduction systems.
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[PubMed:20133179] [WorldCat.org] [DOI] (I p)

Richard C Stewart
Protein histidine kinases: assembly of active sites and their regulation in signaling pathways.
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[PubMed:20117042] [WorldCat.org] [DOI] (I p)

Rong Gao, Ann M Stock
Molecular strategies for phosphorylation-mediated regulation of response regulator activity.
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[PubMed:20080056] [WorldCat.org] [DOI] (I p)

Daelynn R Buelow, Tracy L Raivio
Three (and more) component regulatory systems - auxiliary regulators of bacterial histidine kinases.
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[PubMed:19943903] [WorldCat.org] [DOI] (I p)

Rong Gao, Ann M Stock
Biological insights from structures of two-component proteins.
Annu Rev Microbiol: 2009, 63;133-54
[PubMed:19575571] [WorldCat.org] [DOI] (I p)

Alexander Y Mitrophanov, Eduardo A Groisman
Signal integration in bacterial two-component regulatory systems.
Genes Dev: 2008, 22(19);2601-11
[PubMed:18832064] [WorldCat.org] [DOI] (P p)

Michael T Laub, Mark Goulian
Specificity in two-component signal transduction pathways.
Annu Rev Genet: 2007, 41;121-45
[PubMed:18076326] [WorldCat.org] [DOI] (P p)

Hendrik Szurmant, Robert A White, James A Hoch
Sensor complexes regulating two-component signal transduction.
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[PubMed:17913492] [WorldCat.org] [DOI] (P p)

Rong Gao, Timothy R Mack, Ann M Stock
Bacterial response regulators: versatile regulatory strategies from common domains.
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[PubMed:17433693] [WorldCat.org] [DOI] (P p)

Martijn Bekker, M Joost Teixeira de Mattos, Klaas J Hellingwerf
The role of two-component regulation systems in the physiology of the bacterial cell.
Sci Prog: 2006, 89(Pt 3-4);213-42
[PubMed:17338439] [WorldCat.org] [DOI] (P p)

Thorsten Mascher, John D Helmann, Gottfried Unden
Stimulus perception in bacterial signal-transducing histidine kinases.
Microbiol Mol Biol Rev: 2006, 70(4);910-38
[PubMed:17158704] [WorldCat.org] [DOI] (P p)

J A Hoch, K I Varughese
Keeping signals straight in phosphorelay signal transduction.
J Bacteriol: 2001, 183(17);4941-9
[PubMed:11489844] [WorldCat.org] [DOI] (P p)

A H West, A M Stock
Histidine kinases and response regulator proteins in two-component signaling systems.
Trends Biochem Sci: 2001, 26(6);369-76
[PubMed:11406410] [WorldCat.org] [DOI] (P p)

A M Stock, V L Robinson, P N Goudreau
Two-component signal transduction.
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[PubMed:10966457] [WorldCat.org] [DOI] (P p)

V L Robinson, D R Buckler, A M Stock
A tale of two components: a novel kinase and a regulatory switch.
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[PubMed:10932244] [WorldCat.org] [DOI] (P p)

J A Hoch
Two-component and phosphorelay signal transduction.
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[PubMed:10745001] [WorldCat.org] [DOI] (P p)

C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
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[PubMed:10094672] [WorldCat.org] [DOI] (P p)

K Trach, D Burbulys, M Strauch, J J Wu, N Dhillon, R Jonas, C Hanstein, P Kallio, M Perego, T Bird
Control of the initiation of sporulation in Bacillus subtilis by a phosphorelay.
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[PubMed:1664534] [WorldCat.org] [DOI] (P p)