TuaA/1

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  • Description: lipid carrier sugar transferase, disrupted pseudogene in B. subtilis 168

Gene name tuaA/1
Synonyms yvhA
Essential no
Product lipid carrier sugar transferase
Function biosynthesis of teichuronic acid
Gene expression levels in SubtiExpress: tuaA/1
MW, pI - , -
Gene length, protein length 147 bp, -
Immediate neighbours tuaB, tuaA/2
Gene sequence (+200bp) Protein sequence
Genetic context
TuaA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
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Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, membrane proteins, pseudogenes

This gene is a member of the following regulons

PhoP regulon

The gene

Basic information

  • Locus tag: BSU35609

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-N-acetyl-D-galactosamine + undecaprenyl phosphate = UMP + N-acetyl-alpha-D-galactosaminyldiphospho-undecaprenol (according to Swiss-Prot)
  • Protein family: bacterial sugar transferase family (according to Swiss-Prot)
  • Paralogous protein(s): EpsL

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under conditions of phosphate limitation (PhoP) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Maryam Lahooti, Colin R Harwood
Transcriptional analysis of the Bacillus subtilis teichuronic acid operon.
Microbiology (Reading): 1999, 145 ( Pt 12);3409-3417
[PubMed:10627039] [WorldCat.org] [DOI] (P p)

B Soldo, V Lazarevic, M Pagni, D Karamata
Teichuronic acid operon of Bacillus subtilis 168.
Mol Microbiol: 1999, 31(3);795-805
[PubMed:10048024] [WorldCat.org] [DOI] (P p)

Y Qi, F M Hulett
Role of Pho-P in transcriptional regulation of genes involved in cell wall anionic polymer biosynthesis in Bacillus subtilis.
J Bacteriol: 1998, 180(15);4007-10
[PubMed:9683503] [WorldCat.org] [DOI] (P p)

Wei Liu, F Marion Hulett
Comparison of PhoP binding to the tuaA promoter with PhoP binding to other Pho-regulon promoters establishes a Bacillus subtilis Pho core binding site.
Microbiology (Reading): 1998, 144 ( Pt 5);1443-1450
[PubMed:9611818] [WorldCat.org] [DOI] (P p)