TruA

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Gene name truA
Synonyms ybaH
Essential no
Product pseudouridylate synthase I
Function tRNA modification
Gene expression levels in SubtiExpress: truA
MW, pI 27 kDa, 6.652
Gene length, protein length 741 bp, 247 aa
Immediate neighbours ybaF, rplM
Sequences Protein DNA DNA_with_flanks
Genetic context
TruA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
TruA expression.png
























Categories containing this gene/protein

translation, universally conserved proteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

  • Locus tag: BSU01480

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: tRNA uridine = tRNA pseudouridine (according to Swiss-Prot)
  • Protein family: tRNA pseudouridine synthase truA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

universally conserved protein

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Christine Eymann, Georg Homuth, Christian Scharf, Michael Hecker
Bacillus subtilis functional genomics: global characterization of the stringent response by proteome and transcriptome analysis.
J Bacteriol: 2002, 184(9);2500-20
[PubMed:11948165] [WorldCat.org] [DOI] (P p)