trpE
168
anthranilate synthase (subunit I)
locus
BSU_22680
Molecular weight
57.95 kDa
pI
5.25
function
biosynthesis of tryptophan
product
anthranilate synthase (subunit I)
essential
no
ec
4.1.3.27
synonyms
trpE
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0147 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,375,869 2,377,416
The protein
Catalyzed reaction/ biological activity
chorismate + L-glutamine --> anthranilate + H+ + L-glutamate + pyruvate (according to UniProt)
Protein family
Anthranilate synthase component I family (with [protein|B189AD3E3D18876E1956763182D835A151727392|pabB], according to UniProt)
Structure
[PDB|1I7Q] (from ''Serratia marcescens'', 42% identity, 62% similarity) [Pubmed|11371633]
[AF|P03963]
Effectors of protein activity
subject to feedback inhibtion by tryptophan [Pubmed|4956345]
Biological materials
Mutant
BKE22680 ([gene|48C33A96F3B446440D4D9A86AA07AA3BA244063D|trpE]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCTCTCACTCCTTATG, downstream forward: _UP4_GCTGATGAACAGATTTCTAC
BKK22680 ([gene|48C33A96F3B446440D4D9A86AA07AA3BA244063D|trpE]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGCTCTCACTCCTTATG, downstream forward: _UP4_GCTGATGAACAGATTTCTAC
References
Reviews
Other original publications
The ''trpE'' [wiki|RNA switch]
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Time of last update: 2024-04-24 02:12:14
Author of last update: Melvin.boenninger