trpD

168

anthranilate phosphoribosyltransferase

locus: BSU_22670

Molecular weight: 35.87 kDa

pI: 4.9

Protein length: 338 aa

Gene length: 1017 bp

function: biosynthesis of tryptophan

product: anthranilate phosphoribosyltransferase

essential: no

ec: 2.4.2.18

synonyms: trpD

List of homologs in different organisms, belongs to COG0547 (Galperin et al., 2021)

Gene

Coordinates: 2,374,881  2,375,897

Advertisement

The protein

Catalyzed reaction/ biological activity

• diphosphate + N-(5-phospho-β-D-ribosyl)anthranilate --> 5-phospho-α-D-ribose 1-diphosphate + anthranilate (according to UniProt)

Protein family

• anthranilate phosphoribosyltransferase family (single member, according to UniProt)

Structure

• [PDB|4YI7] (from Acinetobacter sp., 42% identity)
• [AF|P03947]

Biological materials

Mutant

• BKE22670 ([gene|4CD2A930753175B7F533EA6B91478577CE80A29C|trpD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22670 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTCACCGGCAGTAAGGGTTT,  downstream forward: _UP4_CTAAAGCAGAAAGAGGAAGA
• BKK22670 ([gene|4CD2A930753175B7F533EA6B91478577CE80A29C|trpD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22670 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTCACCGGCAGTAAGGGTTT,  downstream forward: _UP4_CTAAAGCAGAAAGAGGAAGA

References

Reviews

• 12966138

Original Publications

• 14976255,3924737,6436812,2422155,8419914,1551827,21815947