trpC

168

indole-3-glycerol-phosphate synthase

locus: BSU_22660

Molecular weight: 27.69 kDa

pI: 5.53

Protein length: 250 aa

Gene length: 750 bp

function: biosynthesis of tryptophan

product: indole-3-glycerol-phosphate synthase

essential: no

ec: 4.1.1.48

synonyms: trpC

List of homologs in different organisms

Gene

Coordinates: 2,374,139 → 2,374,888

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The protein

Catalyzed reaction/ biological activity

• 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H⁺ --> (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO₂ + H₂O (according to UniProt)

Protein family

• TrpC family (single member, according to UniProt)

Structure

• [PDB|1VC4] (from ''Thermus thermophilus'', 36% identity, 49% similarity)
• [AF|P03964]

Biological materials

Mutant

• BKE22660 (Δ[gene|0467447B10EE7C1FDF86022AB6FBDBABFD32A9E5|trpC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22660 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TTTCAAGCATAGATCTCTTC,  downstream forward: _UP4_CATGCTTTGTTTAGGGAGTG
• BKK22660 (Δ[gene|0467447B10EE7C1FDF86022AB6FBDBABFD32A9E5|trpC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22660 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_TTTCAAGCATAGATCTCTTC,  downstream forward: _UP4_CATGCTTTGTTTAGGGAGTG

References

Reviews

• 12966138

Original Publications

• 14976255,3924737,6436812,2422155,8419914,1551827,21815947