Difference between revisions of "TreR"

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(This gene is a member of the following regulons)
(Expression and regulation)
Line 110: Line 110:
 
* '''Regulation:'''  
 
* '''Regulation:'''  
 
** induced by trehalose ([[TreR]]) {{PubMed|8755887}}
 
** induced by trehalose ([[TreR]]) {{PubMed|8755887}}
** repressed by glucose ([[CcpA]]) {{PubMed|18977770}}  
+
** repressed by glucose ([[CcpA]]) {{PubMed|18977770}}
 +
** expressed under conditions of phosphate limitation ([[PhoP]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/21636651 PubMed]
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 
** [[TreR]]: transcription repression {{PubMed|8755887}}
 
** [[TreR]]: transcription repression {{PubMed|8755887}}
 
** [[CcpA]]: transcription repression {{PubMed|18977770}}
 
** [[CcpA]]: transcription repression {{PubMed|18977770}}
 +
** [[PhoP]]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/21636651 PubMed]
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 15:21, 19 October 2011

Gene name treR
Synonyms yfxA
Essential no
Product transcription repressor, (GntR family)
Function regulaation of trehalose utilization
Metabolic function and regulation of this protein in SubtiPathways:
Sugar catabolism
MW, pI 27 kDa, 6.82
Gene length, protein length 714 bp, 238 aa
Immediate neighbours treA, yfkO
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
TreR context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, TreR regulon

The TreR regulon

The gene

Basic information

  • Locus tag: BSU07820

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Hiromi Ujiie, Tomoko Matsutani, Hisashi Tomatsu, Ai Fujihara, Chisato Ushida, Yasuhiko Miwa, Yasutaro Fujita, Hyouta Himeno, Akira Muto
Trans-translation is involved in the CcpA-dependent tagging and degradation of TreP in Bacillus subtilis.
J Biochem: 2009, 145(1);59-66
[PubMed:18977770] [WorldCat.org] [DOI] (I p)

Pavlína Rezácová, Veronika Krejciríková, Dominika Borek, Shiu F Moy, Andrzej Joachimiak, Zbyszek Otwinowski
The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly.
Proteins: 2007, 69(3);679-82
[PubMed:17705272] [WorldCat.org] [DOI] (I p)

L Bürklen, F Schöck, M K Dahl
Molecular analysis of the interaction between the Bacillus subtilis trehalose repressor TreR and the tre operator.
Mol Gen Genet: 1998, 260(1);48-55
[PubMed:9829827] [WorldCat.org] [DOI] (P p)

F Schöck, M K Dahl
Analysis of DNA flanking the treA gene of Bacillus subtilis reveals genes encoding a putative specific enzyme IITre and a potential regulator of the trehalose operon.
Gene: 1996, 175(1-2);59-63
[PubMed:8917076] [WorldCat.org] [DOI] (P p)

F Schöck, M K Dahl
Expression of the tre operon of Bacillus subtilis 168 is regulated by the repressor TreR.
J Bacteriol: 1996, 178(15);4576-81
[PubMed:8755887] [WorldCat.org] [DOI] (P p)