Difference between revisions of "Toxins, antitoxins and immunity against toxins"

From SubtiWiki
Jump to: navigation, search
(Genes in this functional category)
 
(12 intermediate revisions by 2 users not shown)
Line 6: Line 6:
 
* 4.3.1. [[General stress proteins (controlled by SigB)]]
 
* 4.3.1. [[General stress proteins (controlled by SigB)]]
 
* 4.3.2. [[Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]
 
* 4.3.2. [[Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]]
* 4.3.3. [[Acid stress proteins (controlled by YvrI-YvrHa)]]
+
* 4.3.3. [[Acid stress proteins (controlled by SigO-RsoA)]]
 
* 4.3.4. [[Heat shock proteins]]
 
* 4.3.4. [[Heat shock proteins]]
 
* 4.3.5. [[Cold stress proteins]]
 
* 4.3.5. [[Cold stress proteins]]
Line 20: Line 20:
 
none  
 
none  
 
|}}
 
|}}
 +
 +
== Classes of toxin/ antitoxin systems ==
 +
* Type 1: toxic peptide/ antisense RNA
 +
* Type 2: toxic protein/ antitoxin protein
 +
* Type 3: toxic protein/ antagonistic RNA
  
 
== Genes in this functional category ==
 
== Genes in this functional category ==
* ''[[bsrG]]''
+
===Type 1 TA systems:===
 +
* as part of the Skin element
 +
** [[TxpA]]/ ''[[ratA]]''
 +
** [[BsrH]]/ ''[[as-bsrH]]''
 +
 
 +
* as part of [[SPß prophage]]
 +
** [[BsrG]]/ [[SR4]] (= anti-''[[bsrG]]'')
 +
** [[YonT]]/ ''[[as-yonT]]''
 +
 
 +
* as part of the prophage-like element P6
 +
** [[BsrE]]/ [[SR5]]
 +
 
 +
===Type 2 TA systems:===
 +
* as part of [[SPß prophage]]
 +
** [[SunA]]/ [[SunI]]
 +
 
 +
* as part of the Skin element
 +
** [[YqcG]]-[[YqcF]]
 +
 
 +
===Type 3 TA systems:===
 +
 
 +
===Additional candidates===
 +
* [[WapA]]/ [[WapI]]
 
* ''[[ndoA]]''
 
* ''[[ndoA]]''
 
* ''[[ndoAI]]''
 
* ''[[ndoAI]]''
* ''[[ratA]]''
 
 
* ''[[sdpA]]''
 
* ''[[sdpA]]''
 
* ''[[sdpB]]''
 
* ''[[sdpB]]''
Line 38: Line 64:
 
* ''[[spoIISA]]''
 
* ''[[spoIISA]]''
 
* ''[[spoIISB]]''
 
* ''[[spoIISB]]''
* ''[[SR4]]''
+
 
* ''[[txpA]]''
 
 
* [[YokI]]-[[YokJ]]
 
* [[YokI]]-[[YokJ]]
 
* [[YobL]]-[[YobK]]
 
* [[YobL]]-[[YobK]]
 
* [[YxiD]]-[[YxxD]]
 
* [[YxiD]]-[[YxxD]]
* [[YqcG]]-[[YqcF]]
 
 
* [[YeeF]]-[[YezG]]
 
* [[YeeF]]-[[YezG]]
 
* [[YwqJ]]
 
* [[YwqJ]]
Line 54: Line 78:
 
* ''[[yocD]]''
 
* ''[[yocD]]''
 
* ''[[yokG]]''
 
* ''[[yokG]]''
* ''[[yonT]]''
+
 
 
==Key reviews==
 
==Key reviews==
<pubmed> 21041110 19493340 19325885 15864262 12970556 19052321 20156992 21315267 </pubmed>
+
<pubmed> 21041110 19493340 19325885 15864262 12970556 19052321 20156992 21315267 23059907 22434880 23289536 25808661</pubmed>
  
 
=Back to [[categories]]=
 
=Back to [[categories]]=

Latest revision as of 12:22, 28 January 2017

Parent categories
Neighbouring categories
Related categories

none

Classes of toxin/ antitoxin systems

  • Type 1: toxic peptide/ antisense RNA
  • Type 2: toxic protein/ antitoxin protein
  • Type 3: toxic protein/ antagonistic RNA

Genes in this functional category

Type 1 TA systems:

  • as part of the prophage-like element P6

Type 2 TA systems:

Type 3 TA systems:

Additional candidates

Additional candidates (based on similarity)

Key reviews

Sabine Brantl, Natalie Jahn
sRNAs in bacterial type I and type III toxin-antitoxin systems.
FEMS Microbiol Rev: 2015, 39(3);413-27
[PubMed:25808661] [WorldCat.org] [DOI] (I p)

Christopher F Schuster, Ralph Bertram
Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate.
FEMS Microbiol Lett: 2013, 340(2);73-85
[PubMed:23289536] [WorldCat.org] [DOI] (I p)

Sylvain Durand, Natalie Jahn, Ciarán Condon, Sabine Brantl
Type I toxin-antitoxin systems in Bacillus subtilis.
RNA Biol: 2012, 9(12);1491-7
[PubMed:23059907] [WorldCat.org] [DOI] (I p)

Tim R Blower, Francesca L Short, Feng Rao, Kenji Mizuguchi, Xue Y Pei, Peter C Fineran, Ben F Luisi, George P C Salmond
Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes.
Nucleic Acids Res: 2012, 40(13);6158-73
[PubMed:22434880] [WorldCat.org] [DOI] (I p)

Tim R Blower, George P C Salmond, Ben F Luisi
Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners.
Curr Opin Struct Biol: 2011, 21(1);109-18
[PubMed:21315267] [WorldCat.org] [DOI] (I p)

Laurence Van Melderen
Toxin-antitoxin systems: why so many, what for?
Curr Opin Microbiol: 2010, 13(6);781-5
[PubMed:21041110] [WorldCat.org] [DOI] (I p)

Elizabeth M Fozo, Kira S Makarova, Svetlana A Shabalina, Natalya Yutin, Eugene V Koonin, Gisela Storz
Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families.
Nucleic Acids Res: 2010, 38(11);3743-59
[PubMed:20156992] [WorldCat.org] [DOI] (I p)

Kira S Makarova, Yuri I Wolf, Eugene V Koonin
Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes.
Biol Direct: 2009, 4;19
[PubMed:19493340] [WorldCat.org] [DOI] (I e)

Laurence Van Melderen, Manuel Saavedra De Bast
Bacterial toxin-antitoxin systems: more than selfish entities?
PLoS Genet: 2009, 5(3);e1000437
[PubMed:19325885] [WorldCat.org] [DOI] (I p)

Elizabeth M Fozo, Matthew R Hemm, Gisela Storz
Small toxic proteins and the antisense RNAs that repress them.
Microbiol Mol Biol Rev: 2008, 72(4);579-89, Table of Contents
[PubMed:19052321] [WorldCat.org] [DOI] (I p)

Kenn Gerdes, Susanne K Christensen, Anders Løbner-Olesen
Prokaryotic toxin-antitoxin stress response loci.
Nat Rev Microbiol: 2005, 3(5);371-82
[PubMed:15864262] [WorldCat.org] [DOI] (P p)

Finbarr Hayes
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest.
Science: 2003, 301(5639);1496-9
[PubMed:12970556] [WorldCat.org] [DOI] (I p)


Back to categories