Difference between revisions of "Toxins, antitoxins and immunity against toxins"
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| + | == Classes of toxin/ antitoxin systems == | ||
| + | * Type 1: toxic peptide/ antisense RNA | ||
| + | * Type 2: toxic protein/ antitoxin protein | ||
| + | * Type 3: toxic RNA/ antisense RNA | ||
== Genes in this functional category == | == Genes in this functional category == | ||
| + | ===Type 1 TA systems:=== | ||
| + | * ''[[txpA]]''/ ''[[ratA]]'' | ||
| + | * | ||
| + | ===Type 2 TA systems:=== | ||
| + | |||
| + | ===Type 3 TA systems:=== | ||
| + | |||
| + | ===Additional candidates=== | ||
* ''[[bsrG]]'' | * ''[[bsrG]]'' | ||
* ''[[ndoA]]'' | * ''[[ndoA]]'' | ||
* ''[[ndoAI]]'' | * ''[[ndoAI]]'' | ||
| − | * | + | * |
* ''[[sdpA]]'' | * ''[[sdpA]]'' | ||
* ''[[sdpB]]'' | * ''[[sdpB]]'' | ||
| Line 39: | Line 52: | ||
* ''[[spoIISB]]'' | * ''[[spoIISB]]'' | ||
* ''[[SR4]]'' | * ''[[SR4]]'' | ||
| − | + | ||
* [[YokI]]-[[YokJ]] | * [[YokI]]-[[YokJ]] | ||
* [[YobL]]-[[YobK]] | * [[YobL]]-[[YobK]] | ||
Revision as of 07:28, 17 July 2012
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Contents
Classes of toxin/ antitoxin systems
- Type 1: toxic peptide/ antisense RNA
- Type 2: toxic protein/ antitoxin protein
- Type 3: toxic RNA/ antisense RNA
Genes in this functional category
Type 1 TA systems:
Type 2 TA systems:
Type 3 TA systems:
Additional candidates
Additional candidates (based on similarity)
Key reviews
Tim R Blower, George P C Salmond, Ben F Luisi
Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners.
Curr Opin Struct Biol: 2011, 21(1);109-18
[PubMed:21315267]
[WorldCat.org]
[DOI]
(I p)
Laurence Van Melderen
Toxin-antitoxin systems: why so many, what for?
Curr Opin Microbiol: 2010, 13(6);781-5
[PubMed:21041110]
[WorldCat.org]
[DOI]
(I p)
Elizabeth M Fozo, Kira S Makarova, Svetlana A Shabalina, Natalya Yutin, Eugene V Koonin, Gisela Storz
Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families.
Nucleic Acids Res: 2010, 38(11);3743-59
[PubMed:20156992]
[WorldCat.org]
[DOI]
(I p)
Kira S Makarova, Yuri I Wolf, Eugene V Koonin
Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes.
Biol Direct: 2009, 4;19
[PubMed:19493340]
[WorldCat.org]
[DOI]
(I e)
Laurence Van Melderen, Manuel Saavedra De Bast
Bacterial toxin-antitoxin systems: more than selfish entities?
PLoS Genet: 2009, 5(3);e1000437
[PubMed:19325885]
[WorldCat.org]
[DOI]
(I p)
Elizabeth M Fozo, Matthew R Hemm, Gisela Storz
Small toxic proteins and the antisense RNAs that repress them.
Microbiol Mol Biol Rev: 2008, 72(4);579-89, Table of Contents
[PubMed:19052321]
[WorldCat.org]
[DOI]
(I p)
Kenn Gerdes, Susanne K Christensen, Anders Løbner-Olesen
Prokaryotic toxin-antitoxin stress response loci.
Nat Rev Microbiol: 2005, 3(5);371-82
[PubMed:15864262]
[WorldCat.org]
[DOI]
(P p)
Finbarr Hayes
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest.
Science: 2003, 301(5639);1496-9
[PubMed:12970556]
[WorldCat.org]
[DOI]
(I p)
