Difference between revisions of "ThyA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thymidine nucleotides | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thymidine nucleotides | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU17680 thyA] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 32 kDa, 5.502 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 32 kDa, 5.502 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ynzJ]]'', ''[[yncM]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ynzJ]]'', ''[[yncM]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU17680 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU17680 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU17680 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:thyA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:thyA_context.gif]] | ||
Revision as of 13:55, 13 May 2013
- Description: thymidylate synthase A
| Gene name | thyA |
| Synonyms | |
| Essential | no |
| Product | thymidylate synthase A |
| Function | biosynthesis of thymidine nucleotides |
| Gene expression levels in SubtiExpress: thyA | |
| MW, pI | 32 kDa, 5.502 |
| Gene length, protein length | 837 bp, 279 aa |
| Immediate neighbours | ynzJ, yncM |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of nucleotides
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU17680
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP (according to Swiss-Prot)
- Protein family: Bacterial-type thyA subfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- Structure: 1B02
- UniProt: P42326
- KEGG entry: [2]
- E.C. number: 2.1.1.45
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
A Yazgan, G Ozcengiz, M A Marahiel
Tn10 insertional mutations of Bacillus subtilis that block the biosynthesis of bacilysin.
Biochim Biophys Acta: 2001, 1518(1-2);87-94
[PubMed:11267663]
[WorldCat.org]
[DOI]
(P p)
