Difference between revisions of "ThiS"
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| − | * '''Description:''' hydroxyethylthiazole phosphate biosynthesis <br/><br/> | + | * '''Description:''' sulfur carrier protein, hydroxyethylthiazole phosphate biosynthesis <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
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| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || sulfur carrier protein |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thiamine | |style="background:#ABCDEF;" align="center"|'''Function''' || biosynthesis of thiamine | ||
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* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| − | * '''Interactions:''' [[ThiS]]-[[ThiG]] | + | * '''Interactions:''' [[ThiS]]-[[ThiG]] {{PubMed|15362849}} |
* '''Localization:''' | * '''Localization:''' | ||
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=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' | + | * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=1TYG 1TYG] (complex with [[ThiG]]) {{PubMed|15362849}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/O31617 O31617] | * '''UniProt:''' [http://www.uniprot.org/uniprot/O31617 O31617] | ||
Revision as of 15:56, 3 February 2010
- Description: sulfur carrier protein, hydroxyethylthiazole phosphate biosynthesis
| Gene name | thiS |
| Synonyms | yjbS |
| Essential | no |
| Product | sulfur carrier protein |
| Function | biosynthesis of thiamine |
| MW, pI | 7 kDa, 5.501 |
| Gene length, protein length | 198 bp, 66 aa |
| Immediate neighbours | thiO, thiG |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU11680
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: O31617
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578]
[WorldCat.org]
[DOI]
(I p)
Original publications
Ethan C Settembre, Pieter C Dorrestein, Huili Zhai, Abhishek Chatterjee, Fred W McLafferty, Tadhg P Begley, Steven E Ealick
Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex.
Biochemistry: 2004, 43(37);11647-57
[PubMed:15362849]
[WorldCat.org]
[DOI]
(P p)
Joo-Heon Park, Pieter C Dorrestein, Huili Zhai, Cynthia Kinsland, Fred W McLafferty, Tadhg P Begley
Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1).
Biochemistry: 2003, 42(42);12430-8
[PubMed:14567704]
[WorldCat.org]
[DOI]
(P p)
