Difference between revisions of "ThiO"
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Revision as of 12:59, 16 May 2013
- Description: FAD-dependent glycine oxidase
| Gene name | thiO |
| Synonyms | goxB, yjbR |
| Essential | no |
| Product | glycine oxidase |
| Function | biosynthesis of thiamine |
| Gene expression levels in SubtiExpress: thiO | |
| Metabolic function and regulation of this protein in SubtiPathways: Thiamin | |
| MW, pI | 40 kDa, 5.898 |
| Gene length, protein length | 1107 bp, 369 aa |
| Immediate neighbours | tenI, thiS |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU11670
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Glycine + H2O + O2 = glyoxylate + NH3 + H2O2 (according to Swiss-Prot)
- Protein family: DAMOX/DASOX family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: FAD PubMed
- Cofactor(s):
- Effectors of protein activity:
- Interactions: the FAD-containing holoenzyme is a homotetramer PubMed
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: O31616
- KEGG entry: [3]
- E.C. number: 1.4.3.19
Additional information
Expression and regulation
- Sigma factor:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Christopher T Jurgenson, Tadhg P Begley, Steven E Ealick
The structural and biochemical foundations of thiamin biosynthesis.
Annu Rev Biochem: 2009, 78;569-603
[PubMed:19348578]
[WorldCat.org]
[DOI]
(I p)
T P Begley, D M Downs, S E Ealick, F W McLafferty, A P Van Loon, S Taylor, N Campobasso, H J Chiu, C Kinsland, J J Reddick, J Xi
Thiamin biosynthesis in prokaryotes.
Arch Microbiol: 1999, 171(5);293-300
[PubMed:10382260]
[WorldCat.org]
[DOI]
(P p)
Original publications
