ThiL

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  • Description: thiamine-monophosphate kinase

Gene name thiL
Synonyms ydiA, ydxA
Essential no
Product thiamine-monophosphate kinase
Function biosynthesis of thiamine
MW, pI 35 kDa, 5.036
Gene length, protein length 975 bp, 325 aa
Immediate neighbours trnE-Asp, ydiB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ThiL context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU05900

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + thiamine phosphate = ADP + thiamine diphosphate (according to Swiss-Prot)
  • Protein family: thiamine-monophosphate kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Ghislain Schyns, Sébastien Potot, Yi Geng, Teresa M Barbosa, Adriano Henriques, John B Perkins
Isolation and characterization of new thiamine-deregulated mutants of Bacillus subtilis.
J Bacteriol: 2005, 187(23);8127-36
[PubMed:16291685] [WorldCat.org] [DOI] (P p)