TetL

• Description: tetracycline resistance leader peptide
  
  

Gene name	tetL
Synonyms
Essential	no
Product	tetracycline resistance leader peptide
Function	control of tetB expression
Gene expression levels in SubtiExpress: tetL
MW, pI	2 kDa, 10.237
Gene length, protein length	60 bp, 20 aa
Immediate neighbours	tetB, yyaO
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed 500px

Categories containing this gene/protein

resistance against toxins/ antibiotics

The gene

Basic information

• Locus tag: BSU40780

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P23053

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: tetL-tetB (according to DBTBS)

• Expression browser: tetL PubMed

• Sigma factor: SigA PubMed

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

David Bechhofer, Mount Sinai School, New York, USA Homepage

References

R Sakaguchi, H Amano, K Shishido
Nucleotide sequence homology of the tetracycline-resistance determinant naturally maintained in Bacillus subtilis Marburg 168 chromosome and the tetracycline-resistance gene of B. subtilis plasmid pNS1981.
Biochim Biophys Acta: 1988, 950(3);441-4
[PubMed:2844262] [WorldCat.org] [DOI] (P p)