Tdh

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  • Description: L-threonine dehydrogenase

Gene name tdh
Synonyms
Essential no
Product L-threonine dehydrogenase
Function threonine utilization
Gene expression levels in SubtiExpress: tdh
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr
MW, pI 36 kDa, 6.061
Gene length, protein length 1041 bp, 347 aa
Immediate neighbours spoVS, kbl
Sequences Protein DNA Advanced_DNA
Genetic context
Tdh context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Tdh expression.png




























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU16990

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH (according to Swiss-Prot)
  • Protein family: zinc-containing alcohol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2DQ4 (from Thermus thermophilus, 47% identity, 63% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References