Tdh

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  • Description: L-threonine dehydrogenase

Gene name tdh
Synonyms
Essential no
Product L-threonine dehydrogenase
Function threonine utilization
Gene expression levels in SubtiExpress: tdh
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr
MW, pI 36 kDa, 6.061
Gene length, protein length 1041 bp, 347 aa
Immediate neighbours spoVS, kbl
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Tdh context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Tdh expression.png




























Categories containing this gene/protein

utilization of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU16990

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH (according to Swiss-Prot)
  • Protein family: zinc-containing alcohol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2DQ4 (from Thermus thermophilus, 47% identity, 63% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References