TagH

• Description: ABC transporter for teichoic acid translocation (ATP-binding protein)
  
  

Gene name	tagH
Synonyms
Essential	yes PubMed
Product	ABC transporter for teichoic acid translocation (ATP-binding protein)
Function	biosynthesis of teichoic acid
MW, pI	59 kDa, 9.447
Gene length, protein length	1581 bp, 527 aa
Immediate neighbours	ggaA, tagG
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

cell wall synthesis, ABC transporters, biosynthesis of cell wall components, essential genes, membrane proteins

The gene

Basic information

• Locus tag: BSU35700

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: ATP + H₂O + teichoic acid(In) = ADP + phosphate + teichoic acid(Out) (according to Swiss-Prot)

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: TagG-TagH PubMed

• Localization: membrane associated (via TagG) PubMed

Database entries

• Structure:

• UniProt: P42954

• KEGG entry: [2]

• E.C. number: 3.6.3.40

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Kathrin Schirner, Laura K Stone, Suzanne Walker
ABC transporters required for export of wall teichoic acids do not discriminate between different main chain polymers.
ACS Chem Biol: 2011, 6(5);407-12
[PubMed:21280653] [WorldCat.org] [DOI] (I p)

Alex Formstone, Rut Carballido-López, Philippe Noirot, Jeffery Errington, Dirk-Jan Scheffers
Localization and interactions of teichoic acid synthetic enzymes in Bacillus subtilis.
J Bacteriol: 2008, 190(5);1812-21
[PubMed:18156271] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

V Lazarevic, D Karamata
The tagGH operon of Bacillus subtilis 168 encodes a two-component ABC transporter involved in the metabolism of two wall teichoic acids.
Mol Microbiol: 1995, 16(2);345-55
[PubMed:7565096] [WorldCat.org] [DOI] (P p)