Difference between revisions of "SunA"
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| − | + | * '''Description:''' sublancin 168 lantibiotic antimicrobial precursor peptide <br/><br/> | |
| + | |||
| + | {| align="right" border="1" cellpadding="2" | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| + | |''sunA'' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yolG '' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Product''' || sublancin 168 lantibiotic antimicrobial precursor peptide | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Function''' || antimicrobial peptide | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU21480 sunA] | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 5 kDa, 7.963 | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 168 bp, 56 aa | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sunT]]'', ''[[sunI]]'' | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14066]+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' | ||
| + | |- | ||
| + | |colspan="2" | '''Genetic context''' <br/> [[Image:sunA_context.gif]] | ||
| + | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
| + | |- | ||
| + | |colspan="2" |'''[http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sunA_2269521_2269691_-1 Expression at a glance]'''   {{PubMed|22383849}}<br/>[[Image:sunA_expression.png|500px]] | ||
| + | |- | ||
| + | |} | ||
| + | |||
| + | __TOC__ | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/><br/><br/> | ||
| + | <br/><br/> | ||
| + | |||
| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[miscellaneous metabolic pathways]]}}, | ||
| + | {{SubtiWiki category|[[biosynthesis of antibacterial compounds]]}}, | ||
| + | {{SubtiWiki category|[[toxins, antitoxins and immunity against toxins]]}}, | ||
| + | {{SubtiWiki category|[[SP-beta prophage]]}}, | ||
| + | {{SubtiWiki category|[[membrane proteins]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[Abh regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[AbrB regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[Rok regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[YvrHb regulon]]}} | ||
| + | |||
| + | =The gene= | ||
| + | |||
| + | === Basic information === | ||
| + | |||
| + | * '''Locus tag:''' BSU21480 | ||
| + | |||
| + | ===Phenotypes of a mutant === | ||
| + | |||
| + | === Database entries === | ||
| + | |||
| + | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunA.html] | ||
| + | |||
| + | * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG12682] | ||
| + | |||
| + | === Additional information=== | ||
| + | |||
| + | |||
| + | |||
| + | |||
| + | =The protein= | ||
| + | |||
| + | === Basic information/ Evolution === | ||
| + | |||
| + | * '''Catalyzed reaction/ biological activity:''' | ||
| + | |||
| + | * '''Protein family:''' IPP isomerase type 2 family (according to Swiss-Prot) | ||
| + | |||
| + | * '''Paralogous protein(s):''' | ||
| + | |||
| + | === Extended information on the protein === | ||
| + | |||
| + | * '''Kinetic information:''' | ||
| + | |||
| + | * '''Domains:''' | ||
| + | |||
| + | * '''Modification:''' contains a glucose attached to a cysteine residue, glycosylation is essential for its antimicrobial activity {{PubMed|21196935}} | ||
| + | |||
| + | * '''Cofactor(s):''' | ||
| + | |||
| + | * '''Effectors of protein activity:''' | ||
| + | |||
| + | * '''[[SubtInteract|Interactions]]:''' | ||
| + | |||
| + | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | ||
| + | |||
| + | === Database entries === | ||
| + | |||
| + | * '''Structure:''' | ||
| + | |||
| + | * '''UniProt:''' [http://www.uniprot.org/uniprot/P68577 P68577] | ||
| + | |||
| + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21480] | ||
| + | |||
| + | * '''E.C. number:''' | ||
| + | |||
| + | === Additional information=== | ||
| + | |||
| + | =Expression and regulation= | ||
| + | |||
| + | * '''Operon:''' ''sunA'' {{PubMed|16306698}} | ||
| + | |||
| + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sunA_2269521_2269691_-1 sunA] {{PubMed|22383849}} | ||
| + | |||
| + | * '''Sigma factor:''' | ||
| + | |||
| + | * '''Regulation:''' | ||
| + | ** repressed by [[Rok]] [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed] | ||
| + | ** repressed during logrithmic growth ([[AbrB]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/17720793 PubMed] | ||
| + | |||
| + | * '''Regulatory mechanism:''' | ||
| + | ** activated by [[YvrHb]] {{PubMed|16306698}} | ||
| + | ** [[Rok]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed] | ||
| + | ** [[AbrB]]: transcription repression{{PubMed|20817675,17720793}} | ||
| + | ** [[Abh]]: transcription activation {{PubMed|20817675,19465659}} | ||
| + | |||
| + | * '''Additional information:''' the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed] | ||
| + | |||
| + | =Biological materials = | ||
| + | |||
| + | * '''Mutant:''' | ||
| + | |||
| + | * '''Expression vector:''' | ||
| + | |||
| + | * '''lacZ fusion:''' | ||
| + | |||
| + | * '''GFP fusion:''' | ||
| + | |||
| + | * '''two-hybrid system:''' | ||
| + | |||
| + | * '''Antibody:''' | ||
| + | |||
| + | =Labs working on this gene/protein= | ||
| + | |||
| + | =Your additional remarks= | ||
| + | |||
| + | =References= | ||
| + | '''Additional publications:''' {{PubMed|20817675,21196935,21910430}} | ||
| + | <pubmed>12884008,9722542 15743949,17720793,16306698, 19465659 21196935</pubmed> | ||
| + | |||
| + | [[Category:Protein-coding genes]] | ||
Revision as of 20:15, 8 August 2012
- Description: sublancin 168 lantibiotic antimicrobial precursor peptide
| Gene name | sunA |
| Synonyms | yolG |
| Essential | no |
| Product | sublancin 168 lantibiotic antimicrobial precursor peptide |
| Function | antimicrobial peptide |
| Gene expression levels in SubtiExpress: sunA | |
| MW, pI | 5 kDa, 7.963 |
| Gene length, protein length | 168 bp, 56 aa |
| Immediate neighbours | sunT, sunI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
miscellaneous metabolic pathways, biosynthesis of antibacterial compounds, toxins, antitoxins and immunity against toxins, SP-beta prophage, membrane proteins
This gene is a member of the following regulons
Abh regulon, AbrB regulon, Rok regulon, YvrHb regulon
The gene
Basic information
- Locus tag: BSU21480
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: IPP isomerase type 2 family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification: contains a glucose attached to a cysteine residue, glycosylation is essential for its antimicrobial activity PubMed
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P68577
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: sunA PubMed
- Sigma factor:
- Regulatory mechanism:
- Additional information: the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
