Sul

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  • Description: dihydropteroate synthase

Gene name sul
Synonyms
Essential no
Product dihydropteroate synthase
Function biosynthesis of folate
Metabolic function and regulation of this protein in SubtiPathways:
Folate
MW, pI 30 kDa, 5.363
Gene length, protein length 855 bp, 285 aa
Immediate neighbours pabC, folB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Sul context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU00770

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate (according to Swiss-Prot)
  • Protein family: pterin-binding domain (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 1AJZ (from Escherichia coli, 43% identity, 61% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Antoine de Saizieu, Pierre Vankan, Cassandra Vockler, Adolphus P G M van Loon
The trp RNA-binding attenuation protein (TRAP) regulates the steady-state levels of transcripts of the Bacillus subtilis folate operon.
Microbiology (Reading): 1997, 143 ( Pt 3);979-989
[PubMed:9084182] [WorldCat.org] [DOI] (P p)