sufD
168
FeS scaffold, synthesis of Fe-S-clusters
locus
BSU_32700
Molecular weight
48.13 kDa
pI
4.95
function
synthesis of Fe-S-clusters
product
FeS scaffold
essential
yes
synonyms
sufD, yurX
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0719 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,358,664 3,359,977
Phenotypes of a mutant
essential [Pubmed|12682299]
the mutant is viable and Fe-S clusters are dispensable if [protein|search|IspG ]and [protein|search|IspH ]from the MEP pathway for isoprenoid biosynthesis are bypassed by a heterologous mevalonate pathway which allows B. subtilis to synthesize isopentenyl diphosphate and diphosphomevalonate [pubmed|29292548]
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The protein
Catalyzed reaction/ biological activity
synthesis of Fe-S-clusters (the [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]-[protein|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD] complex) [pubmed|29292548]
Protein family
UPF0051 (ycf24) family (with [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB], according to UniProt)
Structure
[PDB|5AWF] (from ''E. coli'', the [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]-[protein|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD] complex, 24% identity) [Pubmed|26472926]
[AF|O32165]
[wiki|Localization]
cytoplasm (homogeneous) [Pubmed|16479537]
Additional information
belongs to the 100 most abundant proteins [PubMed|15378759]
Biological materials
Mutant
MGNA-B586 (yurX::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1585 NBRP B. subtilis, Japan]
References
Reviews
Original Publications
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Time of last update: 2024-04-24 12:29:59
Author of last update: Jstuelk