sufB
168
FeS scaffold, synthesis of Fe-S-clusters
locus
BSU_32670
Molecular weight
52.56 kDa
pI
4.96
function
synthesis of iron-sulfur clusters
product
FeS scaffold
essential
yes
synonyms
sufB, yurU
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0719 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
3,355,593 3,356,990
Phenotypes of a mutant
essential [Pubmed|12682299]
the mutant is viable and Fe-S clusters are dispensable if [protein|search|IspG ]and [protein|search|IspH ]from the MEP pathway for isoprenoid biosynthesis are bypassed by a heterologous mevalonate pathway which allows B. subtilis to synthesize isopentenyl diphosphate and diphosphomevalonate [pubmed|29292548]
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The protein
Catalyzed reaction/ biological activity
synthesis of Fe-S-clusters (the [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]-[protein|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD] complex) [pubmed|29292548]
Protein family
UPF0051 (ycf24) family (with [protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD], according to UniProt)
[wiki|Cofactors]
Fe-S cluster [pubmed|29292548]
Structure
[PDB|5AWF] (from ''E. coli'', the [protein|5991F051C5BAD61A0860BBC64A37DB9D16130998|sufB]-[protein|E966F3808222820C0644DC98F95765B89E6A2551|sufC]-[protein|1A9DA839AB77AF53958CB8426607BEF14F62B85E|sufD] complex, 41% identity) [Pubmed|26472926]
[AF|O32162]
Additional information
subject to Clp-dependent proteolysis upon glucose starvation [PubMed|17981983]
belongs to the 100 most abundant proteins [PubMed|15378759]
Biological materials
Mutant
MGNA-B583 (yurU::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1582 NBRP B. subtilis, Japan]
References
Reviews
Original Publications
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Time of last update: 2024-04-24 08:27:47
Author of last update: Jstuelk