SqhC

• Description: squalene-hopene cyclase, biosynthesis of sporulenes, protection of the spore against oxidative stress PubMed
  
  

Gene name	sqhC
Synonyms
Essential	no
Product	squalene-hopene cyclase
Function	biosynthesis of sporulenes
MW, pI	71 kDa, 7.633
Gene length, protein length	1896 bp, 632 aa
Immediate neighbours	dhaS, sodF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU19320

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

sporulation proteins, resistance against oxidative and electrophile stress

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Squalene = hop-22(29)-ene (according to Swiss-Prot) production of sporulenes, polycyclic terpenoid lipids PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: surrounds the forespores PubMed

Database entries

• Structure:

• UniProt: Q796C3

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: sqhC-sodF PubMed

• Sigma factor: SigE PubMed

• Regulation: expressed during sporulation in the mother cell PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

T Bosak, R M Losick, A Pearson
A polycyclic terpenoid that alleviates oxidative stress.
Proc Natl Acad Sci U S A: 2008, 105(18);6725-9
[PubMed:18436644] [WorldCat.org] [DOI] (I p)