Difference between revisions of "SpoVT"

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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of forespore gene expression
 
|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of forespore gene expression
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU00560 spoVT]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU00560 spoVT]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/lys_threo.html Lys, Thr], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/lys_threo.html Lys, Thr], [http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[mfd]]'', ''[[yabM]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[mfd]]'', ''[[yabM]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB11832&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU00560 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU00560 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU00560 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:spoVT_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:spoVT_context.gif]]

Revision as of 11:55, 13 May 2013

  • Description: transcription activator and repressor of SigG-dependent genes

Gene name spoVT
Synonyms yabL
Essential no
Product transcriptional regulator
Function regulation of forespore gene expression
Gene expression levels in SubtiExpress: spoVT
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr, Stress
MW, pI 19 kDa, 4.676
Gene length, protein length 534 bp, 178 aa
Immediate neighbours mfd, yabM
Sequences Protein DNA Advanced_DNA
Genetic context
SpoVT context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoVT expression.png




























Categories containing this gene/protein

transcription factors and their control, sporulation proteins

This gene is a member of the following regulons

SigF regulon, SigG regulon

The SpoVT regulon

The gene

Basic information

  • Locus tag: BSU00560

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s): AbrB, Abh (only the N-terminal domains (aa 1 through 50) are conserved between SpoVT and the two paralogues)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2W1R (full-length), 2W1T (C-terminal domain)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation: expressed in the forespore (SigG) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Iris Asen, Sergej Djuranovic, Andrei N Lupas, Kornelius Zeth
Crystal structure of SpoVT, the final modulator of gene expression during spore development in Bacillus subtilis.
J Mol Biol: 2009, 386(4);962-75
[PubMed:18996130] [WorldCat.org] [DOI] (I p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)

Fude Yao, Mark A Strauch
Independent and interchangeable multimerization domains of the AbrB, Abh, and SpoVT global regulatory proteins.
J Bacteriol: 2005, 187(18);6354-62
[PubMed:16159768] [WorldCat.org] [DOI] (P p)

Tran Cat Dong, Simon M Cutting, Richard J Lewis
DNA-binding studies on the Bacillus subtilis transcriptional regulator and AbrB homologue, SpoVT.
FEMS Microbiol Lett: 2004, 233(2);247-56
[PubMed:15063493] [WorldCat.org] [DOI] (P p)

I Bagyan, J Hobot, S Cutting
A compartmentalized regulator of developmental gene expression in Bacillus subtilis.
J Bacteriol: 1996, 178(15);4500-7
[PubMed:8755877] [WorldCat.org] [DOI] (P p)