SpoIVCA

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  • Description: site-specific DNA recombinase required for creating the sigK gene (excision of the skin element)

Gene name spoIVCA
Synonyms cisA
Essential no
Product site-specific DNA recombinase
Function excision of the skin element, creation of the sigK gene
MW, pI 57 kDa, 9.498
Gene length, protein length 1500 bp, 500 aa
Immediate neighbours spoIVCB, arsC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SpoIVCA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

DNA repair/ recombination, sigma factors and their control, sporulation proteins

This gene is a member of the following regulons

SigE regulon, SpoIIID regulon

The gene

Basic information

  • Locus tag: BSU25770

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

R Halberg, L Kroos
Sporulation regulatory protein SpoIIID from Bacillus subtilis activates and represses transcription by both mother-cell-specific forms of RNA polymerase.
J Mol Biol: 1994, 243(3);425-36
[PubMed:7966271] [WorldCat.org] [DOI] (P p)

B Kunkel, R Losick, P Stragier
The Bacillus subtilis gene for the development transcription factor sigma K is generated by excision of a dispensable DNA element containing a sporulation recombinase gene.
Genes Dev: 1990, 4(4);525-35
[PubMed:2163341] [WorldCat.org] [DOI] (P p)

T Sato, Y Samori, Y Kobayashi
The cisA cistron of Bacillus subtilis sporulation gene spoIVC encodes a protein homologous to a site-specific recombinase.
J Bacteriol: 1990, 172(2);1092-8
[PubMed:2105293] [WorldCat.org] [DOI] (P p)

B Kunkel, K Sandman, S Panzer, P Youngman, R Losick
The promoter for a sporulation gene in the spoIVC locus of Bacillus subtilis and its use in studies of temporal and spatial control of gene expression.
J Bacteriol: 1988, 170(8);3513-22
[PubMed:2841290] [WorldCat.org] [DOI] (P p)