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spoIVB
168
serine protease (site 1 protease), cleaves [protein|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA] to prepare it for [protein|85247AD09B7A472607B32D57E6318BA6C83EC6BA|ctpB] cleavage, this results in pro-[protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK] processing/activation in the mother-cell, does also cleave [protein|85247AD09B7A472607B32D57E6318BA6C83EC6BA|ctpB]
Molecular weight
45.81 kDa
function
control of [protein|24F7FD5C7C3A68BB2760ABB8CBD8FBD65E5FF7D4|sigK] activation
Genomic Context
This gene is a member of the following
regulons
Gene
Coordinates
2,519,102 → 2,520,382
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The protein
Catalyzed reaction/ biological activity
Self-cleaves 52-Val-|-Asn-53, 62-Ala-|-Phe-63 and 74-Val-|-Thr-75 at the N-terminus of SpoIVB (according to UniProt)
Protein family
PDZ protease [Pubmed|24243021]
[wiki|Domains]
[wiki|PDZ domain] (aa 101 - 187) (according to UniProt)
Peptidase S55 domain (aa 188-426) (according to UniProt)
Structure
[wiki|Localization]
secreted from the forespore to the intracellular space between the mother cell and the forespore [Pubmed|24243021]
Biological materials
Mutant
BKE24230 (Δ[gene|DBB3ED60A7D162B9F2830F81041BC661AA5EC1E7|spoIVB]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE24230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCACTACTTCACTCTCC, downstream forward: _UP4_TGACTGCCGGAGTTTCCGGC
BKK24230 (Δ[gene|DBB3ED60A7D162B9F2830F81041BC661AA5EC1E7|spoIVB]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK24230 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTCACTACTTCACTCTCC, downstream forward: _UP4_TGACTGCCGGAGTTTCCGGC
labs
Simon Cutting, London, UK [http://personal.rhul.ac.uk/uhba/009/bacillus/simon_cutting.html homepage]
References
Reviews
31350897,33538382,35638784 Original Publications
17493131,2106508,10931284,14526016,10931291,1900494,11418578,15292188,9004507,12940997,11741860,16497325,8755877,24243021,15292188,17557826,16818230,30403663