spoIIB

spoIIB
168

spatial and temporal regulation of the dissolution of septal peptidoglycan during engulfment

locus
BSU_28060
Molecular weight
35.77 kDa
pI
4.8
Protein length
Gene length
function
spore morphogenesis
product
facilitator of septal dissolution
essential
no
ec
null
synonyms
spoIIB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG5816 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,863,294 → 2,864,292
Phenotypes of a mutant
reduced sporulation frequency (10 to 20-fold) [pubmed|36066101]
slow and inefficient spore engulfment [pubmed|36066101]
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The protein
Catalyzed reaction/ biological activity
required for efficient localization of the [protein|AAC4BF6FA80115AB90D2B161C1D5383625953616|spoIID]-[protein|14852D54F8B7344AA80D535F8EBBCE11E2B859CF|spoIIM]-[protein|C9817A54C8E72193280E393D7BD3375BD1751738|spoIIP] complex to the septal membrane [pubmed|36066101]
[wiki|Domains]
SPOR domain (aa 175-250) (according to UniProt)
Structure
[AF|P37575]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]
description
[Pubmed|12107147]
regulation
expression is reduced in a [protein|search|SigV] mutant [Pubmed|21926231]
sigma factors
[protein|D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV]: sigma factor, in [regulon|protein:D04629D798E458AD538809BB2B150B7FA81D2C7E|sigV regulon]
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[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]

2024-03-27 14:11:25

ghost

45

613aca2467317449239594c4b7c3f89c11d62127

431135D9B1477154B2CFD0226BD0E3FFFBECC13F

Biological materials
Mutant
BKE28060 (Δ[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE28060 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTCCGCTTCCTCCCTTC,  downstream forward: _UP4_TAAGAGATAGTGCCCTGAGC
BKK28060 (Δ[gene|D98D61CA651AAA415386B1B2B41562E5CF77DEF1|spoIIB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK28060 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTCCGCTTCCTCCCTTC,  downstream forward: _UP4_TAAGAGATAGTGCCCTGAGC
References
17376078,8419299,7559352,12107147,33651833,35638784,36066101

D98D61CA651AAA415386B1B2B41562E5CF77DEF1

Page visits: 2860

Time of last update: 2024-03-28 12:57:44

Author of last update: Jstuelk