Spo0A

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  • Description: phosphorelay regulator, initiation of sporulation <br/><br/>
Gene name spo0A
Synonyms spo0C, spo0G, spoIIL, sof-1
Essential no
Product phosphorelay response regulator
Function initiation of sporulation
Metabolic function and regulation of this protein in SubtiPathways: <br/>Biofilm, Nucleotides (regulation), Ammonium/ glutamate, <br/>Central C-metabolism,Sugar catabolism, Phosphorelay, Stress, <br/>tRNA charging,Lipid synthesis
MW, pI 29 kDa, 5.989
Gene length, protein length 801 bp, 267 aa
Immediate neighbours yqiG, spoIVB
Get the DNA and protein sequences <br/> (Barbe et al., 2009)
Genetic context <br/> Spo0A context.gif
<div align="right"> <small>This image was kindly provided by SubtiList</small></div>

<br/><br/><br/><br/><br/><br/>

The gene

Basic information

  • Locus tag: BSU24220

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Genes controlled by Spo0A

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: receives phosphorylation from Spo0B, dephosphorylation by Spo0E, direct phosphorylation by KinC upon potassium leakage PubMed
  • Cofactor(s):
  • Effectors of protein activity: the phosphorylation state affects DNA binding activity
  • Localization:

Database entries

  • Structure: 1QMP (with phosphorylated aspartate, Geobacillus stearothermophilus), 1FC3 (trans-activation domain, Geobacillus stearothermophilus), 1LQ1 (complex with DNA)
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
    • repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

<pubmed>19995980 20030732 20157337 11286862 20833318 20955377 </pubmed>

Original Publications

<pubmed>20413551 20404177 19528067, 19581368 , 8730857,2106683,3157992, 11254139,1569009, 12067336,10869437, 16385044,9287005, 8127878,9287022, 8231806, 1905258,16452424,2118505,8207022, 12176382, 9733708, 11069677,1391039,12730135, 2437099,8288522,16166384,9495766,2118512,1556084, 18296515,7768874, 3145384, 19114652 20689749 14651647,1537790,9658000, 8509330,14762002, 1846779, 2981817, 15687200, 9477965,8600030, 18840696, 1391039, 14679239, 14976210, 19207565 11679073 12270811 11112444 18978066 20154131 14712656 17157871 15060025 </pubmed>