speA

speA
168

arginine decarboxylase, required for [wiki|biofilm formation]

locus
BSU_14630
Molecular weight
53.42 kDa
pI
5.08
Protein length
Gene length
function
spermidine, polyamine biosynthesis
product
arginine decarboxylase
essential
no
ec
4.1.1.19
synonyms
speA, cad

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1982 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,534,279 → 1,535,751
Phenotypes of a mutant
no [wiki|biofilm formation] [Pubmed|24529384,20876533]
Visit Sartorius.com Visit Sartorius.com
Advertisement
The protein
Catalyzed reaction/ biological activity
H+ + L-arginine --> agmatine + CO2 (according to UniProt)
Protein family
Orn/Lys/Arg decarboxylase class-I family (together with [protein|EEF3E572ED2F23581EB9B48D16B3112B886F7975|yaaO]) (according to UniProt)
[wiki|Cofactors]
PLP (according to UniProt)
Structure
[PDB|2X3L] (from Staphylococcus aureus, 28% identity) [pubmed|20419351]
[AF|P21885]
Paralogous protein(s)
[protein|EEF3E572ED2F23581EB9B48D16B3112B886F7975|yaaO]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]
description
[pubmed|22383849]
Open in new tab

[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]

2024-03-10 09:03:26

Jstuelk

37

ad6c8f56db9062e9c83fbac0dc85f9dfaf893a6e

CC7E9F958C18D17DDF7417E194F5FCE20FCC8311

Biological materials
Mutant
CS210 (''[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]''::''aphA3'', available in [wiki|Colin Harwood]'s and [wiki|Jörg Stülke]'s labs) [Pubmed|27197833]
BKE14630 (Δ[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE14630 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTGTTTTCCCACCTTTG,  downstream forward: _UP4_TAAAAAATAAAAAGCATGCG
BKK14630 (Δ[gene|03E5E41FD7ADA4E9CB70E312FA5F163331C92695|speA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK14630 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAATTGTTTTCCCACCTTTG,  downstream forward: _UP4_TAAAAAATAAAAAGCATGCG
References
24529384,19255484,9723923,20876533,27197833,20419351

03E5E41FD7ADA4E9CB70E312FA5F163331C92695

Page visits: 3834

Time of last update: 2024-03-28 09:43:45

Author of last update: Melvin.boenninger