SlrA

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  • Description: anti-repressor, antagonist of SinR, involved in control of flagellar genes and eps and yqxM-sipW-tasA operons

Gene name slrA
Synonyms
Essential no
Product antagonist of SinR
Function regulation of biofilm formation
Regulation of this protein in SubtiPathways:
Biofilm
MW, pI xx,x kDa, y.yy
Gene length, protein length 156 bp, 52 aa
Immediate neighbours ywcC, ywcB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwcC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry:

Additional information

This gene was only recently identified. PubMed

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binding of SinR resulting in induction of SinR-repressed genes and operons PubMed
  • Protein family:
  • Paralogous protein(s): SinI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: SlrR inhibits activity of SlrA (i. e. binding to SinR) PubMed
  • Localization:

Database entries

  • Structure:
  • KEGG entry: no entry
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yunrong Chai, Roberto Kolter, Richard Losick
Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis.
Mol Microbiol: 2009, 74(4);876-87
[PubMed:19788541] [WorldCat.org] [DOI] (I p)

Kazuo Kobayashi
SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.
Mol Microbiol: 2008, 69(6);1399-410
[PubMed:18647168] [WorldCat.org] [DOI] (I p)