SipU

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  • Description: signal peptidase I

Gene name sipU
Synonyms ycsB
Essential no
Product signal peptidase I
Function protein secretion
Gene expression levels in SubtiExpress: sipU
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 21 kDa, 9.844
Gene length, protein length 561 bp, 187 aa
Immediate neighbours ycsA, yczH
Sequences Protein DNA DNA_with_flanks
Genetic context
SipU context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SipU expression.png



Categories containing this gene/protein

protein secretion, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04010

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins (according to Swiss-Prot)
  • Protein family: peptidase S26 family (according to Swiss-Prot)

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Operon: sipU (according to DBTBS)
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Jan Maarten van Dijl, Groningen, Netherlands

Your additional remarks

References

Reviews

Original publications