SigL

• Description: Sigma subunit of the RNA polymerase, Sigma-54, Sigma L
  
  

Gene name	sigL
Synonyms
Essential	no
Product	RNA polymerase sigma-54 factor (sigma-L)
Function	utilization of arginin, acetoin, and fructose, required for cold adaptation
MW, pI	49,5 kDa, 7.79
Gene length, protein length	1308 bp, 436 amino acids
Immediate neighbours	yvfG, yvfH
Gene sequence (+200bp)	Protein sequence
Genetic context

The gene

Basic information

• Coordinates: 3511532 - 3512839

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Binding to promoters of the -12, -24 type

• Protein family: sigma-54 factor family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • DNA binding domain (H-T-H motif) (324–343)
  • pron box domain (413–421)
  • 3 x Compositional bias domain (6–21),(32–53),(112–136)

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: SigL-RpoB-RpoC

• Localization:

Database entries

• Structure:

• Swiss prot entry: [3]

• KEGG entry: [4]

Expression and regulation

• Operon:

• Sigma factor:

• Regulation: neg. regulated by CcpA PubMed

• Regulatory mechanism: transcriptional roadblock

• Additional information:

Labs working on this gene/protein

Michel Debarbouille, Pasteur Institute, Paris, France Homepage

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed