sdhA

sdhA
168

succinate dehydrogenase (flavoprotein subunit)

locus
BSU_28440
Molecular weight
65.17 kDa
pI
5.71
Protein length
Gene length
function
TCA cycle
product
succinate dehydrogenase (flavoprotein subunit)
essential
no
synonyms
sdhA, citF

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1053 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,906,335  2,908,095
Phenotypes of a mutant
severe growth inhibition upon addition of subinhibitory concentrations of mirubactin C [pubmed|36312962]
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The protein
Catalyzed reaction/ biological activity
menaquinone + succinate --> menaquinol + fumarate [pubmed|38287013]
menaquinone + malate --> menaquinol + enol-oxaloacetate (minor side reaction) [pubmed|38287013]
Protein family
FAD-dependent oxidoreductase 2 family (with [protein|D30D059185DFB828AB0FD07D600DBC3FD0973198|nadB], according to UniProt)
[wiki|Cofactors]
Fe
FAD (according to UniProt)
Structure
[PDB|1NEK] (''E. coli'') [pubmed|12560550]
[AF|P08065]
Modification
phosphorylated [Pubmed|16493705], [Pubmed|17726680]
Effectors of protein activity
Inhibited by 2-(n-Heptyl)-4-hydroxy-quinoline N-oxide [Pubmed|3910107]
Inhibited by enroll-oxaloacetate [pubmed|38287013]
Activated by Cytochrome b558 [Pubmed|6799760]
[wiki|Localization]
attached to the membrane [Pubmed|18763711]
Expression and Regulation
Operons
genes
[gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB]
description
[Pubmed|3036777]
regulation
constitutive
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|2495271], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]→[gene|901F90AFC94CC7140709845333416106D043269D|sdhB]

2024-01-21 16:11:00

ghost

47

6e4216337509de45d76033b51f5046e391052666

7F08B53F36BD96778ADC5652AD8BF65AF07550E2

Other regulations
[protein|CE542AE1A32CCD1ABB259E6159F7A37A8078E189|fsrA]: translation inhibition, [Pubmed|22389480]
Biological materials
Mutant
GP743 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]), cat, available in [wiki|Jörg Stülke]'s lab
GP792 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB])::''phleo'', available in [wiki|Jörg Stülke]'s lab
GP2342 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB])::''kan'', Cre-recombinase is integrated in [gene|8C2DD87E0351BBEE0FD8C0462087CCAD7459AA88|sacA], available in [wiki|Jörg Stülke]'s lab
GP2343 ∆([gene|81429F7802CD4B1F7DFDB6C900D7DA5ECA6B9F3F|sdhC]-[gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]-[gene|901F90AFC94CC7140709845333416106D043269D|sdhB])::''lox72'', Cre-recombinase is integrated in [gene|8C2DD87E0351BBEE0FD8C0462087CCAD7459AA88|sacA], available in [wiki|Jörg Stülke]'s lab
BKE28440 ∆([gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA])::erm  trpC2, available at [http://bgsc.org/getdetail.php?bgscid=BKE28440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGATAGCCCCTCTCCCTC,  downstream forward: _UP4_AAGAAGAAGGTGGCGAAATA
BKK28440 ∆([gene|0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E|sdhA]::kantrpC2, available at [http://bgsc.org/getdetail.php?bgscid=BKK28440 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATGATAGCCCCTCTCCCTC,  downstream forward: _UP4_AAGAAGAAGGTGGCGAAATA
two-hybrid system
''B. pertussis'' adenylate cyclase-based bacterial two hybrid system ([wiki|BACTH]), available in [wiki|Jörg Stülke]'s lab
References
Reviews
33705278,11803018
Original Publications
36815589,2987185,1707123,6401289,6406223,1324713,3036777,2495271,3027051,22389480,17726680,18763711,17726680,16493705,3910107,6799760,12560550,23651456,23880299,12560550,36312962,36422766,38287013

0E1FAF4B3A967CC3882B3DDB3CA2D01FD70A0F7E

Page visits: 3661

Time of last update: 2024-03-28 13:32:00

Author of last update: Jstuelk