sbcD

sbcD
168

exonuclease SbcD homolog

locus
BSU_10640
Molecular weight
43.25 kDa
pI
5
Protein length
Gene length
function
unknown
product
exonuclease SbcD homolog
essential
no
synonyms
sbcD, yixA

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0420 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,143,577  1,144,752
Phenotypes of a mutant
reduced resistance towards electron beams [pubmed|31948638]
reduced formation of [gene|F1969E4C7BAAF70BCBE570F58350C12A3E417539|rpsB] or [gene|144D952B05EBBFF41EC92DF906543EA00475FE69|rpsE] suppressor mutants after mitomycin treatment [pubmed|34339280]
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The protein
Protein family
sbcD family (single member, according to UniProt)
Structure
[PDB|4LTY] (from E. coli, corresponds to aa 1 - 314 of SbcD, 30% identity) [pubmed|24531464]
[AF|P23479]
[wiki|Localization]
Cytoplasm (Homogeneous) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|55A1EF8A10CB398CCD3FDD06D9483FE0DCE31C64|addB]-[gene|49E8BFEC1CAB77DD91E0ED0791EBD480E4871239|addA]-[gene|4D89BFFB1073407A7A1762AFD18B49F3414D6787|sbcD]-[gene|ED825D5B3290BA8F9C92477B1FCC433ADB3C8449|sbcC]-[gene|74E2AB77354355549D14152D3566C9B953A4CB31|hlpB]
description
[Pubmed|22383849]
regulation
positive control by [protein|search|ComK] [Pubmed|7746142]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7746142], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|55A1EF8A10CB398CCD3FDD06D9483FE0DCE31C64|addB]→[gene|74E2AB77354355549D14152D3566C9B953A4CB31|hlpB]

2024-03-11 09:07:21

ghost

109

045c7bb396e5f5521fcc2041130afbaac29b0bd8

E5051999C31DBE142375FC331C2F21A76C29910D

Biological materials
Mutant
GP894 ([gene|4D89BFFB1073407A7A1762AFD18B49F3414D6787|sbcD]-[gene|ED825D5B3290BA8F9C92477B1FCC433ADB3C8449|sbcC]::''kan''), available in [wiki|Jörg Stülke]'s lab [pubmed|22178973]
BKE10640 ([gene|4D89BFFB1073407A7A1762AFD18B49F3414D6787|sbcD]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10640 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAATGCTTTCACCTCTCTT,  downstream forward: _UP4_GGCGTTGAAGAGGAGGATGC
BKK10640 ([gene|4D89BFFB1073407A7A1762AFD18B49F3414D6787|sbcD]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10640 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CAAATGCTTTCACCTCTCTT,  downstream forward: _UP4_GGCGTTGAAGAGGAGGATGC
References
8493111,11948146,22383849,16479537,24531464,30277537,31948638,34339280

4D89BFFB1073407A7A1762AFD18B49F3414D6787

Page visits: 3371

Time of last update: 2024-03-28 01:28:06

Author of last update: Jstuelk