Difference between revisions of "SbcD"

From SubtiWiki
Jump to: navigation, search
Line 33: Line 33:
  
 
__TOC__
 
__TOC__
<br/><br/><br/><br/>
 
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
<br/><br/><br/><br/>
 
 
 
 
<br/><br/><br/><br/>
 
<br/><br/><br/><br/>
  
Line 108: Line 104:
 
=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:''' ''[[sbcD]]-[[sbcC]]-[[yisB]]'' (according to [http://dbtbs.hgc.jp/COG/prom/sbcD-yirY-yisB.html DBTBS])
+
* '''Operon:''' ''[[addB]]-[[addA]]-[[sbcD]]-[[sbcC]]-[[hlpB]]'' {{PubMed|22383849}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sbcD_1143577_1144752_1 sbcD] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=sbcD_1143577_1144752_1 sbcD] {{PubMed|22383849}}
Line 142: Line 138:
 
=References=
 
=References=
  
<pubmed>8493111,11948146 , 16479537</pubmed>
+
<pubmed>8493111,11948146 22383849, 16479537</pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 14:33, 21 September 2012

  • Description: exonuclease SbcD homolog

Gene name sbcD
Synonyms yixA
Essential no
Product exonuclease SbcD homolog
Function unknown
Gene expression levels in SubtiExpress: sbcD
MW, pI 43 kDa, 5.003
Gene length, protein length 1173 bp, 391 aa
Immediate neighbours addA, sbcC
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
SbcD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SbcD expression.png

















Categories containing this gene/protein

DNA repair/ recombination, genetic competence

This gene is a member of the following regulons

ComK regulon

The gene

Basic information

  • Locus tag: BSU10640

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: sbcD family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
    • GP894 (sbcCD::kan), available in Stülke lab
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Pierre Nicolas, Ulrike Mäder, Etienne Dervyn, Tatiana Rochat, Aurélie Leduc, Nathalie Pigeonneau, Elena Bidnenko, Elodie Marchadier, Mark Hoebeke, Stéphane Aymerich, Dörte Becher, Paola Bisicchia, Eric Botella, Olivier Delumeau, Geoff Doherty, Emma L Denham, Mark J Fogg, Vincent Fromion, Anne Goelzer, Annette Hansen, Elisabeth Härtig, Colin R Harwood, Georg Homuth, Hanne Jarmer, Matthieu Jules, Edda Klipp, Ludovic Le Chat, François Lecointe, Peter Lewis, Wolfram Liebermeister, Anika March, Ruben A T Mars, Priyanka Nannapaneni, David Noone, Susanne Pohl, Bernd Rinn, Frank Rügheimer, Praveen K Sappa, Franck Samson, Marc Schaffer, Benno Schwikowski, Leif Steil, Jörg Stülke, Thomas Wiegert, Kevin M Devine, Anthony J Wilkinson, Jan Maarten van Dijl, Michael Hecker, Uwe Völker, Philippe Bessières, Philippe Noirot
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis.
Science: 2012, 335(6072);1103-6
[PubMed:22383849] [WorldCat.org] [DOI] (I p)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)

Mitsuo Ogura, Hirotake Yamaguchi, Kazuo Kobayashi, Naotake Ogasawara, Yasutaro Fujita, Teruo Tanaka
Whole-genome analysis of genes regulated by the Bacillus subtilis competence transcription factor ComK.
J Bacteriol: 2002, 184(9);2344-51
[PubMed:11948146] [WorldCat.org] [DOI] (P p)

G J Sharples, R G Lloyd
Location of the Bacillus subtilis sbcD gene downstream of addAB, the analogues of E. coli recBC.
Nucleic Acids Res: 1993, 21(8);2010
[PubMed:8493111] [WorldCat.org] [DOI] (P p)