sbcC

sbcC
168

DNA exonuclease

locus
BSU_10650
Molecular weight
128.70 kDa
pI
5.29
Protein length
Gene length
function
DNA inter-strand cross-link repair
product
DNA exonuclease
essential
no
synonyms
sbcC, yirY

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0419 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
1,144,749 → 1,148,141
Phenotypes of a mutant
reduced resistance towards electron beams [pubmed|31948638]
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The protein
Protein family
SMC family (with [protein|0136394A52759CEEDD8DE074ED74033C6FFB8435|smc], according to UniProt)
Structure
[PDB|6S6V] (from E. coli, corresponds to aa 1 ... 622, 27% identity) [pubmed|31492634]
[AF|O06714]
[wiki|Localization]
Nucleoid (Mid-cell) [Pubmed|16479537]
Expression and Regulation
Operons
genes
[gene|55A1EF8A10CB398CCD3FDD06D9483FE0DCE31C64|addB]-[gene|49E8BFEC1CAB77DD91E0ED0791EBD480E4871239|addA]-[gene|4D89BFFB1073407A7A1762AFD18B49F3414D6787|sbcD]-[gene|ED825D5B3290BA8F9C92477B1FCC433ADB3C8449|sbcC]-[gene|74E2AB77354355549D14152D3566C9B953A4CB31|hlpB]
description
[Pubmed|22383849]
regulation
positive control by [protein|search|ComK] [Pubmed|7746142]
regulatory mechanism
[protein|08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK]: activation, in [regulon|protein:08CFA2C72931A75532D4289BC1D18A826DE9F9CA|comK regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|7746142], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
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[gene|55A1EF8A10CB398CCD3FDD06D9483FE0DCE31C64|addB]→[gene|74E2AB77354355549D14152D3566C9B953A4CB31|hlpB]

2024-03-11 09:07:21

ghost

109

045c7bb396e5f5521fcc2041130afbaac29b0bd8

E5051999C31DBE142375FC331C2F21A76C29910D

Biological materials
Mutant
MGNA-B290 (yirY::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1289 NBRP B. subtilis, Japan]
GP894 ([gene|4D89BFFB1073407A7A1762AFD18B49F3414D6787|sbcD]-[gene|ED825D5B3290BA8F9C92477B1FCC433ADB3C8449|sbcC]::''kan''), available in [wiki|Jörg Stülke]'s lab [pubmed|22178973]
1A898 ( ''sbcC''::''cat''), [Pubmed|16780573], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A898&Search=1A898 BGSC]
BKE10650 (Δ[gene|ED825D5B3290BA8F9C92477B1FCC433ADB3C8449|sbcC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE10650 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTTAATGCTTAAGGCGATCG,  downstream forward: _UP4_GAGTTGATGTAAGGGAGGAG
BKK10650 (Δ[gene|ED825D5B3290BA8F9C92477B1FCC433ADB3C8449|sbcC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK10650 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CTTAATGCTTAAGGCGATCG,  downstream forward: _UP4_GAGTTGATGTAAGGGAGGAG
labs
[wiki|Peter Graumann], Freiburg University, Germany [http://www.biologie.uni-freiburg.de/data/bio2/graumann/index.htm homepage]
References
Reviews
19308706,22933559
Original Publications
16780573,11948146,16479537,22383849,21170359,30277537,31948638,31492634

ED825D5B3290BA8F9C92477B1FCC433ADB3C8449

Page visits: 2733

Time of last update: 2024-03-27 19:22:11

Author of last update: Jstuelk