Difference between revisions of "RuvA"

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(The gene)
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* '''Catalyzed reaction/ biological activity:'''  
 
* '''Catalyzed reaction/ biological activity:'''  
 +
** inhibits resolution of Holliday junctions by [[RecU]]-[[RuvB]] {{PubMed|24770420}}
  
 
* '''Protein family:''' ruvA family (according to Swiss-Prot)
 
* '''Protein family:''' ruvA family (according to Swiss-Prot)

Revision as of 16:47, 5 May 2014

  • Description: Holliday junction DNA helicase, part of the RuvA-RuvB branch migration translocase

Gene name ruvA
Synonyms
Essential no
Product Holliday junction DNA helicase
Function DNA repair/ recombination
Gene expression levels in SubtiExpress: ruvA
Interactions involving this protein in SubtInteract: RuvA
MW, pI 22 kDa, 5.384
Gene length, protein length 603 bp, 201 aa
Immediate neighbours ruvB, bofC
Sequences Protein DNA DNA_with_flanks
Genetic context
RuvA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RuvA expression.png















Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

  • Locus tag: BSU27740

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: ruvA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559] [WorldCat.org] [DOI] (I p)

S C West
Processing of recombination intermediates by the RuvABC proteins.
Annu Rev Genet: 1997, 31;213-44
[PubMed:9442895] [WorldCat.org] [DOI] (P p)

Original publications

Cristina Cañas, Yuki Suzuki, Chiara Marchisone, Begoña Carrasco, Verónica Freire-Benéitez, Kunio Takeyasu, Juan C Alonso, Silvia Ayora
Interaction of branch migration translocases with the Holliday junction-resolving enzyme and their implications in Holliday junction resolution.
J Biol Chem: 2014, 289(25);17634-46
[PubMed:24770420] [WorldCat.org] [DOI] (I p)

Nora Au, Elke Kuester-Schoeck, Veena Mandava, Laura E Bothwell, Susan P Canny, Karen Chachu, Sierra A Colavito, Shakierah N Fuller, Eli S Groban, Laura A Hensley, Theresa C O'Brien, Amish Shah, Jessica T Tierney, Louise L Tomm, Thomas M O'Gara, Alexi I Goranov, Alan D Grossman, Charles M Lovett
Genetic composition of the Bacillus subtilis SOS system.
J Bacteriol: 2005, 187(22);7655-66
[PubMed:16267290] [WorldCat.org] [DOI] (P p)