RlmCD

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  • Description: rRNA methyltransferase

Gene name rlmCD
Synonyms yerS, yefA
Essential no
Product rRNA methyltransferase
Function 23S rRNA maturation
Gene expression levels in SubtiExpress: rlmCD
MW, pI 51 kDa, 5.707
Gene length, protein length 1377 bp, 459 aa
Immediate neighbours dgkB, yefB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YefA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
RlmCD expression.png
























Categories containing this gene/protein

translation

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU06730

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: methylation of U747 and U1939 in 23S rRNA PubMed
  • Protein family: COG2265
  • Paralogous protein(s): YfjO

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Benoit Desmolaize, Céline Fabret, Damien Brégeon, Simon Rose, Henri Grosjean, Stephen Douthwaite
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA.
Nucleic Acids Res: 2011, 39(21);9368-75
[PubMed:21824914] [WorldCat.org] [DOI] (I p)