rlmCD
168
rRNA methyltransferase
locus
BSU_06730
Molecular weight
51.65 kDa
pI
5.71
function
23S rRNA maturation
product
rRNA methyltransferase
essential
no
ec
2.1.1.190
synonyms
rlmCD, yerS, yefA
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG2265 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
737,603 → 738,982
The protein
Catalyzed reaction/ biological activity
methylation of U747 and U1939 in 23S rRNA [Pubmed|21824914]
S-adenosyl-L-methionine + uridine747 in 23S rRNA --> 5-methyluridine747 in 23S rRNA + H+ + S-adenosyl-L-homocysteine (according to UniProt)
S-adenosyl-L-methionine + uridine1939 in 23S rRNA --> 5-methyluridine1939 in 23S rRNA + H+ + S-adenosyl-L-homocysteine (according to UniProt)
Protein family
[wiki|Methyltransferase superfamily] (according to UniProt)
[wiki|class I-like SAM-binding methyltransferase superfamily] (according to UniProt)
[wiki|Domains]
[wiki|TRAM domain] (aa 6-64) (according to UniProt)
[wiki|Cofactors]
Fe-S cluster [pubmed|29292548]
Structure
[PDB|2BH2] (from ''E. coli'', 32% identity) [Pubmed|15766524]
[AF|O31503]
Paralogous protein(s)
[protein|05392BB2C32B0405799D4F34E5BA55FC936AB943|yfjO]
Biological materials
Mutant
MGNA-A931 (yefA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/931 NBRP B. subtilis, Japan]
BKE06730 (Δ[gene|B97ABE3233A27A7C8273ED9A1E688247DD37FD12|rlmCD]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE06730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATAATCACCTCTAGT, downstream forward: _UP4_TTAAAAGAATAAATAGTCAA
BKK06730 (Δ[gene|B97ABE3233A27A7C8273ED9A1E688247DD37FD12|rlmCD]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK06730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATCTATAATCACCTCTAGT, downstream forward: _UP4_TTAAAAGAATAAATAGTCAA
References
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Time of last update: 2024-04-23 23:53:00
Author of last update: Melvin.boenninger