resE

168

two-component sensor kinase, regulation of aerobic and anaerobic respiration

locus: BSU_23110

Molecular weight: 66.60 kDa

pI: 5.34

Protein length: 589 aa

Gene length: 1770 bp

function: regulation of aerobic and anaerobic respiration

product: two-component sensor kinase

essential: no

synonyms: resE, ypxE

List of homologs in different organisms, belongs to COG5002 (Galperin et al., 2021)

Gene

Coordinates: 2,415,415 → 2,417,184

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The protein

Catalyzed reaction/ biological activity

• autophosphorylation, phosphorylation of [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|resD]
• ATP + protein L-histidine --> ADP + protein N-phospho-L-histidine (according to UniProt)

[wiki|Domains]

• two transmembrane segments
• [wiki|HAMP domain] (aa 194-246) (according to UniProt)
• [wiki|PAS domain] (aa 253-320) (according to UniProt)
• [wiki|Histidine kinase domain] (aa 371-589) (according to UniProt)

Structure

• [PDB|4ZR7] (N-terminal domain)
• [AF|P35164]

Modification

• autophosphorylation on a His residue

Paralogous protein(s)

• [protein|C81F68521F17861D50926D7D8757DC1D2340BC0D|phoR], [protein|E88978809272FAC2520DB4ABCA0554F8028F3451|walK]

[wiki|Localization]

• cell membrane (according to UniProt)

Biological materials

Mutant

• BKE23110 (Δ[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE23110 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GCCTACTACGCTTTTCCAAA,  downstream forward: _UP4_TAAAATCGAGTCTGAATTTG
• BKK23110 (Δ[gene|EA6790EF30D3DDB9670FE52DFD2C5083AB6A48E1|resE]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK23110 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GCCTACTACGCTTTTCCAAA,  downstream forward: _UP4_TAAAATCGAGTCTGAATTTG

References

Reviews

• 23046954

Original Publications

• 16885456,8631715,10094672,8682783,9352926,8631715,11222591,9988472,16825793,26297017,25909364,28899391