ResC

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  • Description: part of heam translocase, required for cytochrome c synthesis

Gene name resC
Synonyms ypxC
Essential yes PubMed
Product part of the ResB-ResC haem translocase
Function cytochrome c biogenesis
Gene expression levels in SubtiExpress: resC
Interactions involving this protein in SubtInteract: ResC
MW, pI 39 kDa, 9.564
Gene length, protein length 1056 bp, 352 aa
Immediate neighbours resD, resB
Sequences Protein DNA DNA_with_flanks
Genetic context
ResC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ResC expression.png
























Categories containing this gene/protein

respiration, essential genes, membrane proteins

This gene is a member of the following regulons

CcpA regulon, PhoP regulon, ResD regulon

The gene

Basic information

  • Locus tag: BSU23130

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed
  • Protein family: ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
    • expressed under conditions of phosphate limitation (PhoP) PubMed
    • repressed by glucose (CcpA) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Umesh Ahuja, Peter Kjelgaard, Benjamin L Schulz, Linda Thöny-Meyer, Lars Hederstedt
Haem-delivery proteins in cytochrome c maturation System II.
Mol Microbiol: 2009, 73(6);1058-71
[PubMed:19682263] [WorldCat.org] [DOI] (I p)

Jong-Hoon Lee, Edgar M Harvat, Julie M Stevens, Stuart J Ferguson, Milton H Saier
Evolutionary origins of members of a superfamily of integral membrane cytochrome c biogenesis proteins.
Biochim Biophys Acta: 2007, 1768(9);2164-81
[PubMed:17706591] [WorldCat.org] [DOI] (P p)

Soo-Keun Choi, Milton H Saier
Mechanism of CcpA-mediated glucose repression of the resABCDE operon of Bacillus subtilis.
J Mol Microbiol Biotechnol: 2006, 11(1-2);104-10
[PubMed:16825793] [WorldCat.org] [DOI] (P p)

M M Nakano, Y Zhu
Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth.
J Bacteriol: 2001, 183(6);1938-44
[PubMed:11222591] [WorldCat.org] [DOI] (P p)

N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol Microbiol: 2000, 36(3);638-50
[PubMed:10844653] [WorldCat.org] [DOI] (P p)

S M Birkey, W Liu, X Zhang, M F Duggan, F M Hulett
Pho signal transduction network reveals direct transcriptional regulation of one two-component system by another two-component regulator: Bacillus subtilis PhoP directly regulates production of ResD.
Mol Microbiol: 1998, 30(5);943-53
[PubMed:9988472] [WorldCat.org] [DOI] (P p)

G Sun, E Sharkova, R Chesnut, S Birkey, M F Duggan, A Sorokin, P Pujic, S D Ehrlich, F M Hulett
Regulators of aerobic and anaerobic respiration in Bacillus subtilis.
J Bacteriol: 1996, 178(5);1374-85
[PubMed:8631715] [WorldCat.org] [DOI] (P p)