Difference between revisions of "ResC"

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* '''Description:''' protein required for cytochrome c synthesis <br/><br/>
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* '''Description:''' part of heam translocase, required for cytochrome c synthesis <br/><br/>
  
 
{| align="right" border="1" cellpadding="2"  
 
{| align="right" border="1" cellpadding="2"  
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|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]  
 
|style="background:#ABCDEF;" align="center"| '''Essential''' || yes [http://www.ncbi.nlm.nih.gov/pubmed/12682299 PubMed]  
 
|-
 
|-
|style="background:#ABCDEF;" align="center"| '''Product''' || unknown
+
|style="background:#ABCDEF;" align="center"| '''Product''' || part of the [[ResB]]-[[ResC]] haem translocase
 
|-
 
|-
 
|style="background:#ABCDEF;" align="center"|'''Function''' || cytochrome c biogenesis
 
|style="background:#ABCDEF;" align="center"|'''Function''' || cytochrome c biogenesis
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=== Basic information/ Evolution ===
 
=== Basic information/ Evolution ===
  
* '''Catalyzed reaction/ biological activity:'''  
+
* '''Catalyzed reaction/ biological activity:''' haem-binding protein,  translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane {{PubMed|19682263}}
  
 
* '''Protein family:''' ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
 
* '''Protein family:''' ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
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* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
  
* '''Interactions:'''
+
* '''Interactions:''' [[ResB]]-[[ResC]] {{PubMed|19682263}}
  
* '''Localization:''' cytoplasm (according to Swiss-Prot)
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* '''Localization:''' cytoplasma membrane {{PubMed|19682263}}
  
 
=== Database entries ===
 
=== Database entries ===
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=References=
 
=References=
  
<pubmed>10844653,8631715,8631715,11222591,9988472, </pubmed>
+
<pubmed>10844653, 19682263, 8631715,11222591,9988472, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:54, 18 August 2009

  • Description: part of heam translocase, required for cytochrome c synthesis

Gene name resC
Synonyms ypxC
Essential yes PubMed
Product part of the ResB-ResC haem translocase
Function cytochrome c biogenesis
MW, pI 39 kDa, 9.564
Gene length, protein length 1056 bp, 352 aa
Immediate neighbours resD, resB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ResC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU23130

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: haem-binding protein, translocation of haem from the cytoplasmic to the extracytoplasmic site of the membrane PubMed
  • Protein family: ccmF/cycK/ccl1/nrfE/ccsA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: cytoplasma membrane PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed under anaerobic conditions (ResD) PubMed
    • expressed under conditions of phosphate limitation (PhoP) PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Umesh Ahuja, Peter Kjelgaard, Benjamin L Schulz, Linda Thöny-Meyer, Lars Hederstedt
Haem-delivery proteins in cytochrome c maturation System II.
Mol Microbiol: 2009, 73(6);1058-71
[PubMed:19682263] [WorldCat.org] [DOI] (I p)

M M Nakano, Y Zhu
Involvement of ResE phosphatase activity in down-regulation of ResD-controlled genes in Bacillus subtilis during aerobic growth.
J Bacteriol: 2001, 183(6);1938-44
[PubMed:11222591] [WorldCat.org] [DOI] (P p)

N E Le Brun, J Bengtsson, L Hederstedt
Genes required for cytochrome c synthesis in Bacillus subtilis.
Mol Microbiol: 2000, 36(3);638-50
[PubMed:10844653] [WorldCat.org] [DOI] (P p)

S M Birkey, W Liu, X Zhang, M F Duggan, F M Hulett
Pho signal transduction network reveals direct transcriptional regulation of one two-component system by another two-component regulator: Bacillus subtilis PhoP directly regulates production of ResD.
Mol Microbiol: 1998, 30(5);943-53
[PubMed:9988472] [WorldCat.org] [DOI] (P p)

G Sun, E Sharkova, R Chesnut, S Birkey, M F Duggan, A Sorokin, P Pujic, S D Ehrlich, F M Hulett
Regulators of aerobic and anaerobic respiration in Bacillus subtilis.
J Bacteriol: 1996, 178(5);1374-85
[PubMed:8631715] [WorldCat.org] [DOI] (P p)